Facile and One- pot synthesis of α- Amino Nitriles by Strecker Reaction Catalyzed by {[Bmim] PINO}as a New Ionic Liquid

Mojtaba Azimoshan; Mohammad Dekamin

doi:10.3390/ecsoc-15-00770

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Facile and One- pot synthesis of α- Amino Nitriles by Strecker Reaction Catalyzed by {[Bmim] PINO}as a New Ionic Liquid

Mojtaba Azimoshan

Mohammad G. Dekamin

¹ Pharmaceutical and Biologically-Active Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran

Published: 31 October 2011 by MDPI in The 15th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-15-00770

Abstract: A simple, convenient, and practical method for the synthesis of α-amino nitriles through a one-pot, three-component Strecker reaction of diverse carbonyl compounds and amines with trimethylsilyl cyanide (TMSCN) under mild conditions in EtOH 96 % has been developed. Reactions proceed efficiently in the presence of a catalytic amounts of new and recoverable ionic liquid of N-butyl-N-methyl imidazolium Phthalimide-N-Oxyl {[Bmim] PINO} at room temperature.

Keywords: α-amino nitriles, Multi-component Reactions (MCRs), Strecker reaction, IOnic Liquids, N-butyl-N-methyl imidazolium Phthalimide-N-Oxyl {[Bmim] PINO}

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Mojtaba Azimoshan

Mohammad Dekamin