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Inflammatory biomarkers in febrile seizure: a comprehensive bibliometric, review and visualization analysis
* 1 , 2 , 1 , 2, 3, 4
1  Mathematics and Informatics Department, Research Center in Informatics and Information Technology, Faculty of Sciences, Lucian Blaga University of Sibiu
2  Pediatric Research and Telemedicine Center in Neurological Diseases, Pediatric Clinical Hospital Sibiu
3  Clinical Department, Faculty of Medicine, Lucian Blaga University of Sibiu
4  Computer and Electrical Engineering Department, Faculty of Engineering, Lucian Blaga University of Sibiu


Background: Inflammatory markers association with many diseases was the subject of many articles and reviews. This study presents a comprehensive bibliometric, review and visualization analysis of inflammatory biomarkers (IB) in the context of febrile seizure (FS) patients.

Methods: The study focused on the IB in FS using (1) bibliometric analysis specific indicators and maps in order to analyze and present the network of authors, journals, universities, and countries, (2) automated literature screening and unsupervised clustering approach for filtering and topic cluster identification.

Results: We conducted a literature mining search on FS research, specifically IB in the context of FS, using automated tools VOSViewer and Adjutant. The presentation and discussions on the resulted bibliometric maps and topic clusters offer a comprehensive overview, status and leading trends on existing research of inflammatory biomarkers in FS.


The analysis using bibliometric and review with graphical presentations can be very useful in investigating and better understanding of the relationship of FS and IB.

Keywords: febrile seizures; inflammatory biomarkers; Adjutant; Vosviewer; bibliometric