The aim of the following research work is to develop the n-propylgallate encapsulated solid lipid nanoparticles (PG-SLNs). And than loading of these PG-SLNs onto Hyaluronic acid based hydrogel suitable for intranasal delivery via applying Risk assessment and QbD methodology. Simple modified solvent injection technique was used for the preparation of the solid lipid nano-particles and response surface quadratic model was employed to get an optimized formulation. The developed nano-formulation (PG-SLNs) were characterized and loaded into Hyaluronic acid based hydrogel. In vitro release and permeation studies were also performed on optimized formulation. The PG-SLNs with an average size of 103±46.04 nm were obtained with PDI of 0.16±0.001, Zeta potential of -36±4.78 mv obtained with percentage yield of NPs was found to be 80.78±0.0125% and encapsulation efficiency was found to be 84±0.477% with loading capacity was about 60±0.034%. Characterization of hydrogel including pH, drug contents measurement, viscosity, swelling index etc studies were also performed. In vitro muco-adhesivity study, in vitro release and permeation study was also performed on final formulation. Release study describe diffusion based release kinetics from hydrogel. Permeation of these nano-carriers from hydrogel showed significant permeation of PG through artificial membrane. It can be concluded that PG-SLNs loaded hydrogel have potential to be delivered through intranasal route.