Metalloporphyrins are the most widely studied catalysts for homogeneous selective oxidation alkenes. An important area of research into their catalytic properties is associated with immobilization of the porphyrin onto a solid support, in order to make the catalyst easier to handle and to separate from the reaction medium, as well as possibly stabilize and/or modify the catalytic performance.Among the mesoporoussilicas, SBA-16 is characterized with unique pore size, high hydrothermal and chemical stability. SBA-16 has a body-centered-cubic structure (Im3m symmetry) of nearly spherical cages, in which each cage is connected with 8 neighboring cages through small openings, which facilitates diffusion and transport of various species, for these reasons they are promising candidates to be used as support for functionalization of porphyrins. The SBA-16 was synthesized in acidic medium by F127 as directing agent and Tetraethylorthosilicate as silica source, respectively and then modified by aminopropyltriethoxysilane (APTES) [2].The synthesis of tetrakis(4-chlorophenyl)porphyrin (TClPP) immobilized into SBA-16 (TClPP@SBA-16) was performed by using ship-in-a-bottle. The characterization of synthesized materials were identified by FT-IR, UV-vis spectroscopy, XRD, nitrogen adsorption-desorption and SEM.in oxidation of cyclohexene. Oxidation of cyclohexene with tertiary butyl-hydroperoxide (TBHP) as oxidantefficientlywas catalyzed to epoxide, ketone and alcohol in presenceacetonitrile as solvent under reflax condition. The obtained products were characterized by using gas chromatography (GC). In addition, leaching and recycling experiments revealed that the catalyst can be repeatedly applied for cyclohexene oxidation for three successive cycles.

In this study, N, S- codoped titania photocatalyst was synthesized through an efficient and straight forward method using a single source, ammonium sulfate, as modification agent of titanium isopropoxide (TTIP) precursor. The catalyst was characterized by X-ray powder diffractometer (XRD), element Analysis of carbon, hydrogen, nitrogen (CHN), scanning electron microscopy (SEM), diffuse reflectance spectroscopy (DRS), energy dispersive X-ray spectroscopy (EDX) and IR spectroscopy. Visible light photocatalytic studies were carried out using methylene blue pollutant. The photodegradation efficiency of methylene blue using N, S-codoped TiO₂ were 98%. Also the degradation of methylene blue was tested using P25 photocatalyst for comparison. The result of photocatalytic degradation of methylene blue indicated that photocatalytic activity of N, S-codoped TiO₂ (98%) was better than P25 (82%) photocatalyst, because the band gap of N, S-codoped TiO₂ is lower than of P25 photocatalyst.

o-Alkoxybenzamides are known to have biological activity. Thus, a group of o-methoxybenzamides constitutes dopamine receptor antagonists. Others, such as o-hexyloxybenzamide, have been found to have antifungal activity. In our search for cocrystal formation utilizing benzamides with the aim of improving solubility, stability and bioavailability during application of the molecules, we have first looked at the single crystal X-ray structures of the three o-alkoxybenzamides, o-allyloxybenzamide (1), o-propoxybenzamide (2), and o-pentoxybenzamide (3).

Reaction of azoles (1,2,4-triazole, benzimidazole, bezotriazole) and dihalogenoderivatives of alkanes and oligoethyleneglykols in a superbasic KOH-dimethylsulfoxide medium was used for the synthesis of bis(azolyl)alkanes and related compounds. The new method does not involve the use of toxic solvents and catalysts, does not require column chromatography for product separation and gives the target compounds in high yields.

Cancer is at present one of the most leading causes of death in the developed countries, and many efforts have been made to discover agents endowed with cytotoxic action. Natural products, with their ability to interact with more than one target, represent in medicinal chemistry a significant source of inspiration for the design of structural analogues with an improved pharmacological profile. Coumarins are an important family of natural and synthetic origin that has been attracting an intense interest in recent years for their remarkable array of biological activities, usually associated to low toxicity. It has been shown that 4-hydroxycoumarins derivatives bearing an aryl group in the 3 position of the coumarin skeleton, inhibit cell proliferation. Furthermore, a recent study shows that the most simple 4-hydroxycoumarin leads to a selective cytoskeleton disorganization in melanoma cells without affecting a non-tumoral fibroblastic cell line. Taking into account previous data about anti-tumor effects of coumarin derivatives we synthesized a new series of compounds structurally related to these, but exhibiting a new pattern of substitution that does not occur in nature and is not present in previously tested compounds. In particular in this communications we investigated the impact of different substituents at C-6 and the introduction of a hydroxyl group in diverse positions on the 3-aryl ring of the 4-hydroxycoumarin moiety on their antiproliferative activity by using two cancer cell lines.

Tyrosinases, better termed polyphenoloxidases (EC 1.14.18.1; monophenol, o-diphenol: oxygen oxidoreductase), are copper-containing monooxygenases catalyzing the o-hydroxylation of monophenols to the corresponding catechols (monophenolase activity) and the oxidation of catechols to the corresponding o-quinones (diphenolase activity).

5-Functionalized hexahydro- and 1,2,3,4-tetrahydropyrimidin-2-ones are currently the focus of considerable interest due to their multifaceted pharmacological profiles. During the last two decades, remarkable progress has been achieved in the development of synthetic approaches to these heterocycles. However, some of them particularly those containing pharmacophoric trifluoromethyl group remained practically unknown. Here we report a general and convenient synthesis of CF₃-substituted 5-functionalized hexahydro- and tetrahydropyrimidin-2-ones. The synthesis started with preparation of readily available N-(1-tosylethyl)urea and N-[(1-acetoxy-2,2,2-trifluoro)ethyl]urea. The prepared ureidoalkylating reagents were treated with sodium enolates of such CH-acids as acetyl acetone, ethyl acetoacetate, and ethyl trifluoroacetoacetate to give either the products of substitution of the tosyl or acetoxy groups, CF₃-containing oxoalkylureas, or their cyclic isomers, 4-hydroxyhexahydropyrimidin-2-ones in high yields and diastereoselectivity. The obtained products were converted into the corresponding CF₃-substituted 5-acyl-1,2,3,4-tetrahydropyrimidin-2-ones using acid-catalyzed dehydration.

Knoevenagel reaction under microwave irradiation of benzophenones and malonate esters lead to coumarocoumarins ( 8,12- dioxatetracyclo[8.8.0.0^2,7.0^13,18]octadeca- 1(10),2,4,6,13,15,17-heptaene-9,11-dione) in good yields

Ultrasonic irradiation was demonstrated to be an efficient technique for activating various organic transformations with short reaction times, fast reaction rate, high yields and sometimes good selectivity. Four new benzo[a]phenoxazinium chlorides possessing isopentylamino, (2-cyclohexylethyl)amino and phenethylamino groups at 5-position of the heterocyclic system were efficiently synthesised under ultrasound irradiation. Conventional heating procedure revealed that the present ultrasonic method provided several advantages in terms of reaction times and product yields. Photophysical studies in ethanol and water, as well as acid-base equilibrium studies of the probes were carried out.

Melamine derivatives are synthesized under green conditions, using water as solvent, from anilines and cyanuril chloride in good yields. The tripodal compounds prepared present funcitionalized aromatic rings that allow former functionalization.