Convenient Synthesis of Novel Amino Acid Coupled Benzanilides

S. El Rayes; Ibrahim Ali; Walid Fathalla

doi:10.3390/ecsoc-11-01299

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Quantitative Regeneration of Carbonyl Compounds from Oximes and hydrazones by Gaseous Nitrogen Dioxide

Convenient Synthesis of Novel Amino Acid Coupled Benzanilides

S. M. El Rayes

¹,

Ibrahim A. I. Ali

¹,

Walid Fathalla

^{*

2}

¹ Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt
² Department of Mathematical and Physical Sciences, Faculty of Engineering, Suez Canal University, Port Said, Egypt

Published: 30 November 2007 by MDPI in The 11th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-11-01299

Abstract: A facile and convenient synthesis of a variety of Methyl 2-(2-Benzoylaminobenzoylamino) alkanoate 4a-d has been developed by the DCC coupling of 2- Benzoylamino-benzoic acid with amino acid methyl ester. Compounds 4a-c were alternatively prepared by the reaction of aminoacid ester with 3,1-benzoxazinone 2 in pyridine. Dipeptides 8a-j were subsequently prepared following the azide coupling method. Compounds 4 and 8 were expected to possess antimicrobial activity.

Keywords: antibiotics, TCS, amino acids and dipeptide, DCC and azide coupling, benzanilides, 3,1-benzoxazinone

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S. El Rayes

Ibrahim Ali

Walid Fathalla