Synthetic Applications of Polystyrene-Supported 1,1,3,3-Tetramethylguanidine

PierFrancesco Biagini; Abel Crespo; Alberto Coelho; Eddy Sotelo

doi:10.3390/ecsoc-11-01335

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Synthesis of (HET)ARYLAMIDOGUANIDINES and their Anticoagulant Activity Evaluation

Synthetic Applications of Polystyrene-Supported 1,1,3,3-Tetramethylguanidine

PierFrancesco Biagini

Abel Crespo

Alberto Coelho

Eddy Sotelo

¹ Unidad de Química Combinatoria, Instituto de Farmacia Industrial (IFI), Spain
² Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, 15782, Spain

Published: 30 November 2007 by MDPI in The 11th International Electronic Conference on Synthetic Organic Chemistry session Solid Phase Chemistry and Combinatorial Synthesis

https://doi.org/10.3390/ecsoc-11-01335

Abstract: Several applications of polystyrene-supported 1,1,3,3-tetramethylguanidine (PS-TMG) in synthetic organic chemistry have been explored. This study evidenced the effectiveness and versatility of this new member of the supported guanidine superbases as an attractive candidate to replace the bases usually employed in organic synthesis during the implementation of environmentally friendly preparative processes.

Keywords: Supported reagents, TMG, base

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PierFrancesco Biagini

Abel Crespo

Alberto Coelho

Eddy Sotelo