Abstract: Briefly introduced the status and related theories foundation of Theoretical Informatics (TI) and Systems Biology (SB). These two disciplines were compared and analyzed, mainly from the background, epistemological approach, informational energy of open systems, which these three aspects can demonstrate the two disciplines be of connected or similar attributes or characteristics, to indirectly discourse the necessity, the rationality, the feasibility and the vital significance of the establishment and researches for TI. Explore how to draw, reference SB model of development to promote the prosperity and great development of TI