Efficient synthesis of coumarin-chalcones hybrids as new scaffold with antibacterial interest

Lourdes Santana; Ysabel Santos; Silvia Serra; Saleta Vazquez-Rodriguez

doi:10.3390/ecsoc-14-00403

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Efficient synthesis of coumarin-chalcones hybrids as new scaffold with antibacterial interest

Lourdes Santana

¹,

Ysabel Santos

²,

Silvia Serra

¹,

Saleta Vazquez-Rodriguez

^{*

1}

¹ Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782, Spain.
² Departement of Microbiology and parasitology, CIBUS building-Faculty of Biology, Univesrsity of Santiago de Compostela, 15782, Spain.

Published: 19 October 2010 by MDPI in The 14th International Electronic Conference on Synthetic Organic Chemistry session Natural Products Chemistry

https://doi.org/10.3390/ecsoc-14-00403

Abstract: Due to the potential antibacterial activity of the chalcone and coumarin moieties, hybrid compounds containing both structures have been synthesized in good yield using the Knoevenagel reaction as the key step.

Keywords: Coumarin, Chalcone, Knoevenagel , Antibacterial

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Lourdes Santana

Ysabel Santos

Silvia Serra

Saleta Vazquez-Rodriguez