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Quantitative Synthesis of α-Amino Nitriles through Strecker Reaction of Aldimines with TMSCN Catalyzed by Tetrabutylammonium phthalimide-N-oxyl
Published:
30 October 2010
by MDPI
in The 14th International Electronic Conference on Synthetic Organic Chemistry
session Natural Products Chemistry
Abstract: Tetrabutylammonium phthalimide-N-oxyl (TBAPINO) was used as an efficient organocatalyst to catalyze the Strecker reaction of diverse aldimines with trimethylsilylcyanide (TMSCN) in EtOH. The reaction proceeded smoothly at room temperature to afford the corresponding α-aminonitriles in quantitative yields under mild reaction conditions.
Keywords: α-Amino Nitriles; Strecker Reaction; Aldimines; Nucleophilic Organocatalysis; Tetrabutylammonium phthalimide-N-oxyl (TBAPINO); TMSCN
