New thiosemicarbazones based on quinoline scaffold as anticancer iron chelators

Jaroslaw Polanski; Robert Musiol; Maciej Serda

doi:10.3390/ecsoc-14-00441

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New thiosemicarbazones based on quinoline scaffold as anticancer iron chelators

Jaroslaw Polanski

Robert Musiol

^*,

Maciej Serda

¹ University of Silesia, Institute of Chemistry, Szkolna 9, 40-007 Katowice, POLAND.

Published: 31 October 2010 by MDPI in The 14th International Electronic Conference on Synthetic Organic Chemistry session Microwave Assisted Synthesis

https://doi.org/10.3390/ecsoc-14-00441

Abstract: Novel quinoline derivatives was designed as anticancer iron chelators. Structurally they combine active moieties of known quinoline and thiosemicarbazone bioeffectors. For the synthetic part of study we applied microvawe assisted techniques MAOS. Resulted compounds exhibited interesting anticancer activities against HCT116 cancer cells.

Keywords: Thiosemicarbazones, quinoline, anticancer, microwave

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Jaroslaw Polanski

Robert Musiol

Maciej Serda