Optimization of synthesis of dioctyl phthalate using response surface methodology

Shahrara Afshar; Heshmatollah Najafabadi; Mansoor Amani

doi:10.3390/ecsoc-14-00455

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Optimization of synthesis of dioctyl phthalate using response surface methodology

Shahrara Afshar

¹,

Heshmatollah Ebraimi Najafabadi

²,

Mansoor Amani

¹ College of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran
² Department of Chemistry, Sharif University of Technology, P.O. Box 11155-3516, Tehran, Iran

Published: 30 October 2010 by MDPI in The 14th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-14-00455

Abstract: Esterification reaction of phthalic anhydride with 2-ethyl hexanol was investigated using sulfated titanium dioxide nano catalyst. The influence of reaction time, catalyst amount and alcohol/anhydride molar ratio was studied using a rotatable central composite design (CCD). The optimum values of factors were: 83 min for the time, 9 %wt catalyst, 9:1 alcohol:anhydride molar ratio. The maximum yield of 93% at optimum conditions was obtained.

Keywords: Optimization, Response surface methodology, Esterification, Dioctyl phthalate

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Shahrara Afshar

Heshmatollah Najafabadi

Mansoor Amani