Synthesis and Biological Evaluation of Some Coumarin Derivatives

M. Khalil; Samir M. El-Rayes; M. Y. El-Kady; M. E. Abd El-Fattah

doi:10.3390/ecsoc-14-00490

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AZO COMPOUNDS WITH ANTIMICROBIAL ACTIVITY

Synthesis and Biological Evaluation of Some Coumarin Derivatives

M. Khalil

¹,

Samir M. El-Rayes

^{*

1},

M. Y. El-Kady

²,

M. E. Abd El-Fattah

¹ Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt.
² -Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.

Published: 02 November 2010 by MDPI in The 14th International Electronic Conference on Synthetic Organic Chemistry session Natural Products Chemistry

https://doi.org/10.3390/ecsoc-14-00490

Abstract: Starting from 7-hydroxy-4-methylcoumarin which was prepared via pechmann condensation, some comarin derivatives were synthesized depending on several reactions which are condensation with aldehydes, Mannich reaction, alkylation and reaction with hydrazine hydrate. The prepared compounds were evaluated for their microbiological activity against Grame +ve bacteria Bacillus Subtilis, Gram –ve bacteria Serratia marcenses and fungi Trichoderma Sp.

Keywords: 7-hydroxy-4-methylcoumarin, 7-hydroxy-4-styryl-2H-chromen-2-one, antimicrobial activity

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M. Khalil

Samir M. El-Rayes

M. Y. El-Kady

M. E. Abd El-Fattah