Cissus incisa is an endemic plant from Mexico and the southern United States. In traditional Mexican medicine it is used to treat respiratory and skin infections, although it has not been scientifically validated until now. The current study was undertaken primarily to investigate the phytochemistry composition of this plant. From GC/MS technique was identified several compounds, among them, series of triterpenoids. These compounds are widely distributed in the plant kingdom. They have been investigated for their biological activities, such as anticancer and antimicrobial.