Scientific and technological advances have achieved a substantial increment in life expectancy. Unfortunately, the life extension is associated with the presence of neurodegenerative diseases. Interestingly, a common cause of these pathologies is associated with the development of abnormal proteins that induce voltage-gated anionic channel (VDAC) blocking, with a subsequent decrease in their conductance, mitochondrial dysfunction and finally neuronal apoptosis. Neuroglobin, a metalloprotein with antioxidant and antiapoptotic properties can sterically prevent their blockade and partially counteract the production of reactive species, another common cause shared by neurodegenerative pathologies. Subtle mutations of neuroglobin have been documented at advanced age, therefore neuroglobin replacement therapy was conceived as a neuroprotective therapeutic tool. In this review, we discuss the most recent findings regarding the relationship neuroglobin/VDAC in Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, and Parkinson's disease. Finally, we discuss some future alternatives to study the neuroglobin and VDAC interaction.
Now we closed the publication phase and launched the post-publication phase of the conference. REVIEWWWERS'08 Brainstorming Workshop is Now Open from 2023-Jan-01 to 2023-Jan-31. MOL2NET Committee, Authors, and Validated Social Media Followers Worldwide are invited to Post Moderated Questions/Answers, Comments, about papers. Please kindly post your public Answers (A) to the following questions in order to promote interchange of scientific ideas.
My Question (Q) to you:
Q1. Is it necessary to have any mutations of neuroglobin to apply neuroglobin replacement therapy? Or is it possible to identify the risk and apply at people that could be potentially affected in the future?
Dear author thanks in advance for your kind support answering the questions.
Now, the conference publication phase is close but you can answer here directly as a post-publication comment. However, in case you want to elaborate your answers in a more structured way in the form of a short communication we can upload it free-of-cost on your behalf to the CATCHTOHIT-03: Congress on Acad. Transl. Res. for Companies Helping to Height. Innov. & Tech., Bilbao-Cambridge, MA, USA, 2022. https://mol2net-08.sciforum.net/catchtohit-03
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Happy new year 2023.
Thanks and kind regards,
CHEMBIOMOL Committee Assistant, Maider Baltasar Marchueta.
