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Preparation of Glibenclamide Nanoparticles
1 , 2 , 3 , * 1
1  Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 612 42 Brno, Czech Republic
2  Nanotechnology Centre, VSB – Technical University of Ostrava, 17. listopadu 15/2172, 708 33 Ostrava – Poruba, Czech Republic
3  Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Odbojarov 10, 832 32, Bratislava 3, Slovakia

Abstract: One of the progressive ways for increasing oral bioavailability of drug substances with poor solubility is nanoparticles preparation. Glibenclamide (Biopharmaceutical Classification System class II) was chosen as a model compound with low solubility and high permeability. Nanoparticles were prepared either by the antisolvent precipitation – solvent evaporation method or by the emulsion solvent evaporation method. Sodium dodecyl sulphate and macrogol 6000 were used as stabilizing excipients in aqueous solutions with the mass concentrations of 1, 3 and 5%. Acetone and dichloromethane were used as glibenclamide solvents. Ten samples were characterized by dynamic light scattering. The particles size of seven samples ranged from 4.4 to 27.0 nm.
Keywords: Glibenclamide; nanoparticles; Sodium dodecyl sulphate; Macrogol; dynamic light scattering