Abstract: Recently, environmental pollution and the economic crisis have become very important global challenges. Nowadays, industrial and manufacturing units including chemicals and pharmaceutical companies show propensity to environmentally friendly protocols that is so-called green and sustainable protocols. In this field, green chemistry plays an efficient role. One of the important strategies in green chemistry is multicomponent reactions (MCRs). On the other hand, catalysts are powerful tools to improve reaction conditions. Application of nanoscience in this field leads to a wide range of academic and industrial researches to obtain greenprocedures.2-Amino-4H-pyran derivatives are important molecules because of their biologicalactivities such asantiallergic, antitumor, antibacterial, diuretic, anti-coagulant, and anti-anaphylactic. Also reusability of catalysts is an important challenge in green chemistry. Magnetic nanoparticles (MNPs) are used as efficient catalysts, because they are easily separable and recyclable and have high surface area vs. bulk materials that improves their activity. In continuation of our interest in the application of new catalysts in organic synthesis via MCRs, herein, we represent an environmentally friendly synthesis of 4H-pyrans via a green one-pot threecomponent reaction using MNPs CuFe2O4 as catalyst under mild reaction conditions in good to excellent yields.