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Quantitative Synthesis of α-Amino Nitriles through Strecker Reaction of Aldimines with TMSCN Catalyzed by Tetrabutylammonium phthalimide-N-oxyl
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1  Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran

Abstract: Tetrabutylammonium phthalimide-N-oxyl (TBAPINO) was used as an efficient organocatalyst to catalyze the Strecker reaction of diverse aldimines with trimethylsilylcyanide (TMSCN) in EtOH. The reaction proceeded smoothly at room temperature to afford the corresponding α-aminonitriles in quantitative yields under mild reaction conditions.
Keywords: α-Amino Nitriles; Strecker Reaction; Aldimines; Nucleophilic Organocatalysis; Tetrabutylammonium phthalimide-N-oxyl (TBAPINO); TMSCN