Previous Article in event
Release of model amino acids by ester linkage photolysis from fused 2-oxo-2H-benzopyranyl conjugatesPrevious Article in session
Next Article in event Next Article in session
Quantitative Synthesis of α-Amino Nitriles through Strecker Reaction of Aldimines with TMSCN Catalyzed by Tetrabutylammonium phthalimide-N-oxyl
Published: 30 October 2010 by MDPI in The 14th International Electronic Conference on Synthetic Organic Chemistry session Natural Products Chemistry
Abstract: Tetrabutylammonium phthalimide-N-oxyl (TBAPINO) was used as an efficient organocatalyst to catalyze the Strecker reaction of diverse aldimines with trimethylsilylcyanide (TMSCN) in EtOH. The reaction proceeded smoothly at room temperature to afford the corresponding α-aminonitriles in quantitative yields under mild reaction conditions.
Keywords: α-Amino Nitriles; Strecker Reaction; Aldimines; Nucleophilic Organocatalysis; Tetrabutylammonium phthalimide-N-oxyl (TBAPINO); TMSCN