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Synthesis of Acetaminophen by Liquid Phase Beckmann Rearrangement of 4-Hydroxyacetophenone Oxime over Nano-Ordered Zn-MCM-41
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1  Pharmaceutical and Biologically-Active Compounds Research Laboratory, Department of chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran

Abstract: Nano-OrderedZn-MCM-41 materials were synthesized using different zinc sources and applied for liquid phase Beckman rearrangement of 4-hydroxyacetophenone oxime to acetaminophen. The reaction conditions such as amount of the catalyst and solvent were optimized to afford acetaminophen in high yields. it Aprotic solvents with high dielectric constant are preferred for this transformation.
Keywords: Acetaminophen; Beckmann Rearrangement; 4-Hydroxyacetophenone Oxime, Zn-MCM-41; Nano-Ordered Catalyst.