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Synthesis of Acetaminophen by Liquid Phase Beckmann Rearrangement of 4-Hydroxyacetophenone Oxime over Nano-Ordered Zn-MCM-41
Published: 30 October 2010 by MDPI in The 14th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: Nano-OrderedZn-MCM-41 materials were synthesized using different zinc sources and applied for liquid phase Beckman rearrangement of 4-hydroxyacetophenone oxime to acetaminophen. The reaction conditions such as amount of the catalyst and solvent were optimized to afford acetaminophen in high yields. it Aprotic solvents with high dielectric constant are preferred for this transformation.
Keywords: Acetaminophen; Beckmann Rearrangement; 4-Hydroxyacetophenone Oxime, Zn-MCM-41; Nano-Ordered Catalyst.