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Synthesis and Biological Evaluation of Some Coumarin Derivatives
Published: 02 November 2010 by MDPI in The 14th International Electronic Conference on Synthetic Organic Chemistry session Natural Products Chemistry
Abstract: Starting from 7-hydroxy-4-methylcoumarin which was prepared via pechmann condensation, some comarin derivatives were synthesized depending on several reactions which are condensation with aldehydes, Mannich reaction, alkylation and reaction with hydrazine hydrate. The prepared compounds were evaluated for their microbiological activity against Grame +ve bacteria Bacillus Subtilis, Gram –ve bacteria Serratia marcenses and fungi Trichoderma Sp.
Keywords: 7-hydroxy-4-methylcoumarin, 7-hydroxy-4-styryl-2H-chromen-2-one, antimicrobial activity