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Synthesis and Biological Evaluation of Some Coumarin Derivatives
1 , * 1 , 2 , 1
1  Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt.
2  -Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.

Abstract: Starting from 7-hydroxy-4-methylcoumarin which was prepared via pechmann condensation, some comarin derivatives were synthesized depending on several reactions which are condensation with aldehydes, Mannich reaction, alkylation and reaction with hydrazine hydrate. The prepared compounds were evaluated for their microbiological activity against Grame +ve bacteria Bacillus Subtilis, Gram –ve bacteria Serratia marcenses and fungi Trichoderma Sp.
Keywords: 7-hydroxy-4-methylcoumarin, 7-hydroxy-4-styryl-2H-chromen-2-one, antimicrobial activity