Over the past few decades, magnetic nanoparticles have been considered by many researchers due to their unique physicochemical, magnetic and optical properties and extensive applications in the field of biomedical (such as magnetic resonance imaging (MRI), drug delivery system and magnetic hyperthermia), catalysis, information technology, telecommunication and environmental remediation, destruction of organic pollutants such as dyes, etc. In this work, it has been attempted to synthesize Ni_0.1Cu_0.1Zn_0.8Fe₂O₄ by both gel-auto combustion and microwave-assisted methods and the resulting powders were characterized by different analysis involved, XRD, SEM, IR, EDS, VSM and UV-Vis spectra. The effect of these two ferrites on the absorption and degradation of methylene orange dye was studied at different concentrations (100, 160 and 200 ppm). The average crystalline size of MNPs obtained by gel-auto combustion and MW-assisted, were 77.9 and 44.1 nm, respectively. The specific magnetization curves exhibit ferromagnetism of soft magnetic materials and the (Ms) values of samples were 20.64 and 52.89 (emu/g) for MNPs obtained by gel-auto combustion and MW-assisted, respectively. Finally, both ferrites showed high absorption of methylene orange dye in water under UV-Vis irradiation (λ> 400 nm).