Regioselective and Sequential Mono- and Diamination of 5,7-Dichloro-pyrido[2,3-d]pyrimidine-2,4-diones

Dang Van Tinh; Wolfgang Stadlbauer

doi:10.3390/ecsoc-11-01331

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Regioselective and Sequential Mono- and Diamination of 5,7-Dichloro-pyrido[2,3-d]pyrimidine-2,4-diones

Dang Van Tinh

^{1, 2},

Wolfgang Stadlbauer

^{*

3}

¹ School of Pharmacy, University of Medicine and Pharmacy at Hochiminh City 41 Dinh Tien Hoang Str., Dist. 1, Ho Chi Minh City, Vietnam
² Institut für Chemie, Organic Synthesis Group, Karl-Franzens-University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria
³ Institut für Chemie, Organic Synthesis Group, Karl-Franzens-University of Graz Heinrichstrasse 28, A-8010 Graz (Austria)

Published: 30 November 2007 by MDPI in The 11th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-11-01331

Abstract: 5-Amino- and 5,7-diamino-pyrido[2,3-d]pyrimidine-2,4-diones were prepared easily from the corresponding 5,7-dichloro-pyrido[2,3-d]pyrimidine-2,4-diones with aliphatic and aromatic amines. The 7-monoazides, obtained by azidation of the chlorides, were converted to iminophosphoranes by reaction with triphenylphosphane via Staudinger reaction. Hydrolysis produced in one step 7-amino-pyrido[2,3-d]pyrimidine-2,4-diones.

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Dang Van Tinh

Wolfgang Stadlbauer