Synthesis of new possible monoamine oxidase inhibitors

Eugenio Uriarte; Lourdes Santana; Giovanna Delogu; Maria Matos; Silvia Serra

doi:10.3390/ecsoc-14-00474

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A Triterpenoid Saponin from the Seeds of Ricinus communis

Synthesis of new possible monoamine oxidase inhibitors

Eugenio Uriarte

¹,

Lourdes Santana

¹,

Giovanna Delogu

²,

Maria Joao Matos

¹,

Silvia Serra

^{*

1, 2}

¹ Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
² Department Farmaco Chimico Tecnologico, Facoltà di Farmacia, Università Degli Studi di Cagliari, Cagliari 09124, Italy.

Published: 31 October 2010 by MDPI in The 14th International Electronic Conference on Synthetic Organic Chemistry session Natural Products Chemistry

https://doi.org/10.3390/ecsoc-14-00474

Abstract: We have generated different resveratrol-coumarin hybrids with the aim of evaluate their biological applications and their pharmacological properties, particularly the inhibitory activity of monoamine oxidase enzyme. According to that, a first series of 3-aryl-4-hydroxycoumarins has been synthesized starting from aryl boronic acids and phenyliodonium zwitterions precursors by a palladium-catalyzed coupling reaction.

Keywords: coumarin, MAO, Suzuki reaction

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Eugenio Uriarte

Lourdes Santana

Giovanna Delogu

Maria Matos

Silvia Serra