In this survey, novel Pd catalysts supported on Chitosan and EDTA were prepared for the first time and their structures were appropriately demonstrated by various analytical and identification techniques including FT-IR, EDX, XRD, SEM, TEM, TGA, DRS and BET. The Catalysts were successfully employed in the Heck Cross-Coupling Reactions (HCR) with good to excellent yields. Different aryl halides carrying Br, Iodine and Cl were used in the HCR with different acrylates to synthesis cinnamic acid and its valuable ester derivatives. The catalysts show a variety of advantages such as excellent thermal stability, easy recovery by simple filtration, more than five cycles of reusability with no significant decrease in their efficacy, biodegradability, biocompatibility and brilliant result in the HCR with low loaded Pd on the substrate.