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A new efficient route to 2-alkylsemicarbazides
1 , 2 , 2 , 1 , * 1
1  N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., 119991 Moscow, Russian Federation
2  Russian Technological University, 86 Vernadsky Avenue, 119571 Moscow, Russian Federation


Synthesis of hardly available 2-alkylsemicarbazides and their hydrochlorides from semicarbazide hydrochloride has been developed. This general and efficient protocol is based on preparation of acetone semicarbazone, its N2-alkylation in the presence of sodium hydride, and hydrolysis under mild conditions.

Keywords: Semicarbazides, semicarbazones, alkylation, hydrolysis