A new catalyst-free microwave-assisted one-pot four-component synthesis of 1,4-dihydroquinolines in aqueous media

Mostafa Safari; Shahrzad Javanshir

doi:10.3390/ecsoc-14-00431

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A new catalyst-free microwave-assisted one-pot four-component synthesis of 1,4-dihydroquinolines in aqueous media

Mostafa Safari

Shahrzad Javanshir

¹ Heterocyclic Chemistry Research Laboratory, Department of Chemistry,

Published: 30 October 2010 by MDPI in The 14th International Electronic Conference on Synthetic Organic Chemistry session Microwave Assisted Synthesis

https://doi.org/10.3390/ecsoc-14-00431

Abstract: A novel rapid one-pot four-component reaction between resorcinol, aromatic aldehydes, malononitrile and ammonium acetate in aqueous media was performed under microwave irradiation for the synthesis of 1,4-dihydroquinoline derivatives. The main advantages of this method are the short reaction time, high yields, despite absence of any catalyst, and simple work-up.

Keywords: 1,4-dihydroquinolines, Multicomponent reaction; Microwave-assisted

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Mostafa Safari

Shahrzad Javanshir