Synthesis of 1,3,5-tris(2-aryloxyethyl)isocyanurates by esterification of 1,3,5-tris(2-hydroxyethyl)isocyanurate under microwave irradiation in a direct and efficient way in solvent free conditions.

3-Nitro-4-chloroquinoline 3 was converted to the azides 5/6. The azides were cyclized on thermolysis to furoxanes 7/8. Deoxygenation to furazane 9 was achieved by reaction with triphenylphosphane. The reaction conditions were studied by differential scanning calorimetry (DSC). The azides 5/6 gave with triphenylphosphane the phosphazenes 10/11, which were cleaved to the aminoquinolone 12

ZSM-11 samples were synthesized and treated with small amounts of Pt and Au substrates (1 & 4wt% metal). The effects of this treatment on the structural, textural, and catalytic properties of the employed zeolite were studied. The acidity of Pt and Au-containing ZSM-11 solids was determined. The techniques employed were XRD, pyridine adsorption using FTIR-technique, N2 adsorption at -196 ºC, and catalytic conversion of isopropyl alcohol at 110-275 ºC using a flow technique. The treatment of ZSM-11with Au and Pt-species resulted in a structure collapse of 23, 19 %, respectively without much affecting its crystallite size. The specific surface areas of zeolites decrease slightly by treatment with Pt and Au species while their microporosity increased from 79 to 91%. All catalysts investigated behaved as selective dehydration solids having activities which increased by treating with Pt or Au species. The samples treated with 4 wt% Pt showed the biggest activity. The selectivity towards propene formation was also found to increase by treatment with Pt or Au species.

A new kind of surfactants with chelating properties named N-Acyl ethylenediamine triacetate (N-acyl ED3A) of different hydrocarbon chain lengths were synthesized from anhydrous ethylene diamine, fatty acid chlorides (Capryloyl, Lauroyl, myristoyl, palmitoyl, stearoyl or oleoyl chloride) and chloroacetic acid. The chemical structures of the prepared compounds were confirmed using different spectroscopic techniques, primarily Fourier transform infrared spectroscopy and nuclear magnetic resonance. The surface properties including surface and interfacial tension, foaming height, emulsification power, calcium ion stability, stability to hydrolysis and critical micelle concentration (CMC) were determined. The trisodium N-acyl ethylenediamine triacetates have been found to combine the properties of strong surfactancy, extreme mildness with a high tolerance to water hardness, and ability to chelate metal ions, which indicates a promising application prospect in many fields.

Starting from 7-hydroxy-4-methylcoumarin which was prepared via pechmann condensation, some comarin derivatives were synthesized depending on several reactions which are condensation with aldehydes, Mannich reaction, alkylation and reaction with hydrazine hydrate. The prepared compounds were evaluated for their microbiological activity against Grame +ve bacteria Bacillus Subtilis, Gram –ve bacteria Serratia marcenses and fungi Trichoderma Sp.

We have studied the complexation between an adamantane derivative labelled with the fluorescent probe Alexa 488 and the three natural cyclodextrins (-, - and -CD) by Fluorescence Correlation Spectroscopy (FCS), demonstrating the ability of this technique to detect association and to determine the corresponding equilibrium constants with no need for changes in the fluorescence properties of the guest. At low CD concentrations the observed increase of the diffusion time of the probe is mainly due to the complexation of the adamantyl moiety, but further changes are observed when increasing CD concentration that are attributed to the formation of CD aggregates. These aggregates appear at quite low CD concentrations and seem to be formed by a small number of CD molecules. These results show the potential of FCS for the study of CD self-assembly, a recently-recognized phenomenon that could be used to improve certain applications of CDs.

Two new disazo compounds containing 4,4'-diaminostilbene- 2,2'-disulfonic acid and 4,4'-diaminobenzanilide as middle components were synthesized and characterized by thin layer chromatography (TLC), electronic spectra (VIS), FT/IR and 13 C-NMR spectroscopy. According to the results of the colouristic evaluation, the studied azo compounds can be ranged in the direct dye's class. The individual human skin tolerance for these azo compounds was evaluated by in vivo imagistic skin studies and the obtained results indicate that, from dermatologic point of view, the azo compounds may be used as textile dyes. Further, the compounds were evaluated for antibacterial activity against Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa and Proteus vulgaris by the disk diffusion method. The screening data releaved that the studied azo compounds exhibited antimicrobial activity against most of the tested species, presenting a particular interest against Staphylococcus aureus and Escheria coli.

2-(5-Mercapto-4-phenyl-4H-[1,2,4]triazol-3-ylmethyl)-6-p-tolyl-4,5-dihydro-2H-pyridazin-3-one (3) was prepared according to the established sequenced procedures 1-3 . Subsequently by using selected alkylating agents; compounds 4a-c were prepared via regioselective S alkylation procedure4. Alternatively, compounds 5a-c were prepared via regioselective addition procedure 4 . Under Mannich condition, some interesting compounds 7a,b and 8a,b were successfully prepared. On the other hand, the azides 10 and 15 coupled with amino acid esters 11a-d and 15a- d to give amino acids derivatives 12a-d and 16a-d in good to moderate yield respectively. The structural elucidation of products is reported and also some of the products were screened for their antimicrobial activity.

1-acetyl-3-[(5-bromo-2-acetoxy-phenylmethylene)-amino]-4-oxo-imidazolidin-2-thione (2) and 5-acetyl-3-[(5-bromo-2-hydroxy-phenylmethylene)-amino]-4-oxo-imidazolidin-2-thione(3)prepared by Acylation of 3-[(5-bromo-2-hydroxy-phenylmethylene)-amino]-4-oxo-imidazolidin-2-thione(1) by different method. The reaction of 3-[(5-bromo-2-hydroxy-phenylmethylene)-amino]-4-oxo-imidazolidin-2-thione (1) with bromine in presence of glacial acetic acid resultthe 5-bromo- 3-[(5-bromo-2-hydroxy-phenylmethylene)-amino]-4-oxo -imidazolidin-2-thione (4). The Acylation of compound (4) with acetic anhydride led to formation 5-bromo-1,5-diacetyl-3-[(5-bromo-2-acetoxy-phenylmethylene)-amino]-4-oxo-imidazolidin-2-thione (5). The hydrazinolysis of compound (1) with hydrazine hydrated led to formation of 2, 4-dihydrazino-3-[(5-bromo-2-hydroxy-phenylmethyl)-amino]-imidazolidine (6). The condensation of compound (1) with different aldehyde led to formation of (7a-c). The action of acetic anhydride on compounds (7a-c) under reflux led to formation of (8a-c).

5-(3,5-Dibromo-2-hydroxyphenyl)-2,3,4-trihydro-1,2,4-triazole-3-thione(4) and 3-[(5-bromo-or 3,5-dibromo-2-hydroxy-phenylmethylene)-amino]-4-oxo-imidazolinidin-2-thiones(7a,b)were prepared via the reaction of 2,3,5trisubstituted benzaldehyde thiosemicarbazones(2a,b)with bromine in acetic acid and ethylchloroacetate in presence of fused sodium acetate. While 5-(4-methylphenyl-2-[3,5-dibromo-2-hydroxy-phenylmethylene)-hydrazion]-thiazole(5) prepared via reaction of (2b) with 4-methyl phenacylbromide. Acylation of (2b) and (5) with acetic anhydride gave the corresponding diacetyl derivatives (3) and (6).