Novel transition metal(II) complexes, [M(L₁)₂Cl₂] and [M(L₂)₂Cl₂], were synthesized from the reaction of MCl₂.nH₂O (M = Co, Ni, Cu) with (Z)-1-(1-(1H-indol-3-yl)ethylideneamino)quinolin-2(1H)-one (L₁) or (E)-1-(2-hydroxybenzylideneamino)quinolin-2(1H)-one (L₂). The ligands were obtained from coumarin. N-amino quinoline-2-one (2) has been synthesized by the reflux of coumarin (1) with hydrazine hydrate in ethanol for 12 hr. The azomethines (L₁, L₂) were prepared from the corresponding aryl aldehydes. The synthesized compounds were and characterized by element chemical analysis, molar conductance, magnetic susceptibility measurements, and spectral (electronic, and FT-IR) studies. The IR spectral data suggest the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, an octahedral geometry has been assigned for all complexes. The free ligands and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties.

Dye sensitized solar cells (DSSCs) are currently attracting widespread academic and commercial interest for the conversion of sunlight into electricity because of their low cost and high DSSCs are similar to natural photosynthesis in the initial processes involving in light-harvesting and charge separation. To gain a better understanding of the role of the sensitizer, particularly of its electronic structure and excited-state properties in the efficiency of dye-sensitized solar cell devices, we have carried out Density Functional Theory (DFT) and Time Dependent DFT (TDDFT) calculations in solution of the geometry, electronic structure and optical absorption spectra of a Chl a derivative (methyl 3-devinyl-3-carboxypyropheophorbide a; Phe a) and its Mg-Phe a and Zn-Phe a -derived sensitizers. Calculations have been performed using the B3LYP exchange correlations functional, as implemented in the Gaussian03 program package. The geometries of were first optimized in vacuum using density functional 6-311G(d) method. Solvation effects were included by means of the Conductor-like polarizable continuum model (C-PCM) in the dichloromethane solvent. There are good agreement between the experimental and the TDDFT calculated absorption spectra of three Different Chlorophyllous sensitizers. From the orbital analysis and the orbital spatial orientation of HOMO and LUMO for Phe a, Mg-Phe a and Zn-Phe a -derived sensitizers, the result shows that Phe a seems to provide higher photo-to-electric conversion efficiencies.

The condensation of 3-methoxy or 3-ethoxy-2-hydroxybenzaldehyde and 1,2 diamine -2-methylpropane, to yield at the dianionic hexadentate Schiff base ligands H₂ Lⁿ (H₂ L¹ , H₂ L² respectively). The ligands have been characterised by elemental analysis, IR, ¹H and ¹³C NMR spectroscopies and mass spectrometry (ES). The crystal structure of the two ligands was solved by X-ray crystallography, revealing its ability to bind metal centres.

Valine and phenylalanine were used as model amino acids for the synthesis of ester conjugates with a fused oxobenzopyran, in order to evaluate its applicability as a photocleavable protecting group for solution phase organic and peptide synthesis. The behaviour of the corresponding conjugates towards photocleavage was evaluated by irradiation in methanol/HEPES buffer (80:20) and acetonitrile/HEPES buffer (80:20) solutions, in a photochemical reactor at different wavelengths (300 and 350 nm), followed by HPLC/UV monitoring.

Tetrabutylammonium phthalimide-N-oxyl (TBAPINO) was used as an efficient organocatalyst to catalyze the Strecker reaction of diverse aldimines with trimethylsilylcyanide (TMSCN) in EtOH. The reaction proceeded smoothly at room temperature to afford the corresponding α-aminonitriles in quantitative yields under mild reaction conditions.

In order to evaluate the application of new oxobenzopyrano[6,7-d]oxazoles as photocleavable protecting groups, a series of model alanine and β-alanine ester conjugates were synthesised by reaction with the corresponding halomethylated heterocycles. Photocleavage studies of conjugates in methanol/HEPES buffer (80:20) solution at different wavelengths of irradiation (250, 300 and 350 nm) revealed the quantitative release of the amino acids, the best results being obtained for 8-(chloromethyl)-2-methyl-6-oxo-6H-benzopyrano[6,7-d]oxazole.

Novel quinoline derivatives was designed as anticancer iron chelators. Structurally they combine active moieties of known quinoline and thiosemicarbazone bioeffectors. For the synthetic part of study we applied microvawe assisted techniques MAOS. Resulted compounds exhibited interesting anticancer activities against HCT116 cancer cells.

5H-Pyrido[4,3-b]indole was obtained from 3-formylindole in 16% overall yield by Jackson and Shannon modification of the Pomeranz-Fristch isoquinoline synthesis. The final cyclisation occurred but the removal of the tosyl group and oxidation of the dihydrocompound was not efficient. Changes in the concentration of the acid catalyst gave 29% as the best yield for the last step. An NMR study of the cyclisation is described.

The additives influence on the photochemical reactivity of 1,3-dinitrobenzoyleneurea was studied. Amines having different chemical nature, iso-propylic alcohol and sodium salt of mandelic acid proved to be efficient additive to activate the title compounds activity. The additive role is electron and/or H-atom transfer ability improving.

In this study, immobilized Iron (III) complex of meso-tetrakis(p-chlorophenyl) porphyrin [Fe_III(TClPP)] on modified silica gel by 3-aminopropyl group has been used as a heterogeneous catalysts for oxidation of benzhydrol by t-butyl hydroproxide (TBH). The reaction was performed at room temperature to afford benzophenone in high yields and short reaction time. Furthermore, the catalyst can be reused for at least 3 reaction cycles without significant lose of its activity.