Mining bacterial genomes to reveal secret synergy
Published: 28 December 2018 by American Society for Biochemistry & Molecular Biology (ASBMB) in Journal of Biological Chemistry
American Society for Biochemistry & Molecular Biology (ASBMB), Volume 293; 10.1074/jbc.h118.006669
Abstract: The medical treatment of infectious diseases often requires combination therapies that blend two molecules to enhance drug efficacy. Nature does the same. In a new article, Mrak et al. identify and functionally characterize natural products from Streptomyces rapamycinicus that show synergistic antifungal activity with the well-known immunosuppressant metabolite rapamycin, produced by the same strain. The genomic co-association of the two biosynthetic gene clusters paves the way toward new strategies to discover synergistic pairs of antibiotics through large-scale genome mining.
Keywords: Treatment, Efficacy, Genome Mining, combination therapies, genomes, functionally, Mining Bacterial, discover synergistic, clusters paves