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Christian Demitri published an article in March 2019.
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(2005 - 2019)
(2005 - 2019)
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Article 0 Reads 0 Citations Rheological analysis of thermo-responsive alginate/PNIPAAm graft copolymers synthesized by gamma radiation Published: 01 March 2019
Radiation Physics and Chemistry, doi: 10.1016/j.radphyschem.2018.10.021
Article 0 Reads 0 Citations Mono- and Bi-Phasic Cellulose Acetate Micro-Vectors for Anti-Inflammatory Drug Delivery Published: 18 February 2019
Pharmaceutics, doi: 10.3390/pharmaceutics11020087
In recent years, different processing technologies have been engineered to fabricate capsules or particles with peculiar properties (e.g., swelling, pH-sensitive response) at the micro and sub-micrometric size scale, to be used as carriers for controlled drug and molecular release. Herein, the development of cellulose acetate (CA) micro-carriers with mono- (MC) or bi-phasic (BC) composition is proposed, fabricated via electrohydrodynamic atomization (EHDA)—an electro-dropping technology able to micro-size polymer solution by the application of high voltage electrostatic forces. Image analysis allows identification of the process parameters to optimize morphology, in terms of size distribution and shape. Meanwhile, an accurate rheological study has enabled investigating the interface between CA solutions with different viscosities to optimize BC systems. Release tests have confirmed that BC carriers can retain the drug more efficiently in acidic conditions, also providing a more gradual and sustained release until six days, with respect to MC carriers. Hence, all these results have proven that biphasic architecture significantly improves the capability of CA microcarriers to release ketoprofen lysinate, thus suggesting a new route to design core/shell systems for the retarded oral administration of anti-inflammatory drugs.
BOOK-CHAPTER 0 Reads 0 Citations Investigating the Structure-Related Properties of Cellulose-Based Superabsorbent Hydrogels Published: 27 November 2018
Hydrogels [Working Title], doi: 10.5772/intechopen.80986
Article 0 Reads 1 Citation A Randomized, Double-Blind, Placebo-Controlled Study of Gelesis100: A Novel Nonsystemic Oral Hydrogel for Weight Loss Published: 13 November 2018
Obesity, doi: 10.1002/oby.22347
Objective This study aims to assess the efficacy and safety of Gelesis100, a novel, nonsystemic, superabsorbent hydrogel to treat overweight or obesity. Methods The Gelesis Loss Of Weight (GLOW) study was a 24‐week, multicenter, randomized, double‐blind, placebo‐controlled study in patients with BMI ≥ 27 and ≤ 40 kg/m2 and fasting plasma glucose ≥ 90 and ≤ 145 mg/dL. The co‐primary end points were placebo‐adjusted weight loss (superiority and 3% margin super‐superiority) and at least 35% of patients in the Gelesis100 group achieving ≥ 5% weight loss. Results Gelesis100 treatment caused greater weight loss over placebo (6.4% vs. 4.4%, P = 0.0007), achieving 2.1% superiority but not 3% super‐superiority. Importantly, 59% of Gelesis100‐treated patients achieved weight loss of ≥ 5%, and 27% achieved ≥ 10% versus 42% and 15% in the placebo group, respectively. Gelesis100‐treated patients had twice the odds of achieving ≥ 5% and ≥ 10% weight loss versus placebo (adjusted OR: 2.0, P = 0.0008; OR: 2.1, P = 0.0107, respectively), with 5% responders having a mean weight loss of 10.2%. Patients with prediabetes or drug‐naive type 2 diabetes had six times the odds of achieving ≥ 10% weight loss. Gelesis100 treatment had no apparent increased safety risks. Conclusions Gelesis100 is a promising new nonsystemic therapy for overweight and obesity with a highly desirable safety and tolerability profile.
Article 0 Reads 0 Citations Reflectometric System for Continuous and Automated Monitoring of Irrigation in Agriculture Published: 07 November 2018
Advances in Agriculture, doi: 10.1155/2018/2849250
In this work, a time domain reflectometry (TDR)-based system for continuous and diffused monitoring of soil water content in agriculture is presented. The proposed TDR-based system employs elongate sensing elements (SEs). In practical application, each wire-like SE is buried along the cultivation row to be monitored, and through a single TDR measurement it is possible to retrieve the water content profile of the cultivation along the length of the SE. By connecting the TDR-based monitoring system to the irrigation machines, it would be possible to automatically start/stop irrigation based on the actual water requirement of the cultivations, thus favoring precision agriculture and enhancing irrigation efficiency. To demonstrate the feasibility of the proposed monitoring solution, a dedicated hardware+software platform was developed and the TDR-based system was experimented in open-field cultivations.
Article 0 Reads 0 Citations A Feasibility Study of Processing Polydimethylsiloxane–Sodium Carboxymethylcellulose Composites by a Low-Cost Fused Depo... Published: 01 September 2018
Materials, doi: 10.3390/ma11091578
Additive manufacturing (AM) techniques allow the construction of complex physical models reproducing the content of a specific CAD file, and, among them, Fused Deposition Molding (FDM) stands out for its many advantages. The aim of the present work is to perform a feasibility study of 3D printing of a model of human heart to be used to simulate surgical operations or for training through a two-step method based on extrusion and FDM processes. To this purpose, typical extrusion instrumentation and a simple and low-cost FDM printer are employed, in combination with a thermoplastic polydimethylsiloxane (PDMS), chosen for its transparency, flexibility, and high resistance to multiple agents and aging. To improve its tactile properties and mimic the slimy effect of living organs, sodium carboxymethylcellulose (Na–CMC) fibrils are added to it. The starting materials, the neat PDMS filament and the composite one, are deeply characterized in terms of structural, thermal, and rheological properties in order to fix the most suitable extrusion and FDM parameters. The composite filaments show larger diameter and roughness, which cause undesirable effects during 3D printing, such as episodic nozzle obstruction, and exhibit a faster degradation, making the FDM step difficult. Nevertheless, the major issues are related to the low crystallinity degree of the employed polymer. The feasibility study carried out leads to the printing of composite layers, even though far from the desired final target. Possible solutions to print the fully characterized Na–CMC/PDMS composite are addressed in the conclusion of this work.