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Thomas Nann     Senior Scientist or Principal Investigator 
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Thomas Nann published an article in October 2018.
Research Keywords & Expertise See all
0 A
0 Fluorescence
0 Luminescence
0 Nanoparticles
0 Photoluminescence
0 Quantum Dots
Top co-authors See all
I. P. Parkin

518 shared publications

Department of Chemistry

Nicolas H. Voelcker

131 shared publications

ARC Centre of Excellence in Convergent Bio−Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, South Australia 5095, Australia

Steven J.P. McInnes

26 shared publications

Future Industries Institute, University of South Australia, Mawson Lakes 5095, Australia

Nathan Hollingsworth

6 shared publications

Department of Chemistry, University College London, London WC1H 0AJ, UK

Renee V. Goreham

2 shared publications

The MacDiarmid Institute, Wellington 6012, New Zealand

1 Followers
128
Publications
129
Reads
2
Downloads
881
Citations
Publication Record
Distribution of Articles published per year 
(2000 - 2018)
Total number of journals
published in
 
31
 
Publications See all
Article 1 Read 0 Citations Cadmium-Free Quantum Dots as Fluorescent Labels for Exosomes Garima Dobhal, Deanna Ayupova, Geoffry Laufersky, Zeineb Aye... Published: 02 October 2018
Sensors, doi: 10.3390/s18103308
DOI See at publisher website ABS Show/hide abstract
Quantum dots are attractive alternatives to organic fluorophores for the purposes of fluorescent labeling and the detection of biomarkers. They can also be made to specifically target a protein of interest by conjugating biomolecules, such as antibodies. However, the majority of the fluorescent labeling using quantum dots is done using toxic materials such as cadmium or lead due to the well-established synthetic processes for these quantum dots. Here, we demonstrate the use of indium phosphide quantum dots with a zinc sulfide shell for the purposes of labeling and the detection of exosomes derived from the THP-1 cell line (monocyte cell line). Exosomes are nano-sized vesicles that have the potential to be used as biomarkers due to their involvement in complex cell processes. However, the lack of standardized methodology around the detection and analysis of exosomes has made it difficult to detect these membrane-containing vesicles. We targeted a protein that is known to exist on the surface of the exosomes (CD63) using a CD63 antibody. The antibody was conjugated to the quantum dots that were first made water-soluble using a ligand-exchange method. The conjugation was done using carbodiimide coupling, and was confirmed using a range of different methods such as dynamic light scattering, surface plasmon resonance, fluorescent microscopy, and Fourier transform infrared spectroscopy. The conjugation of the quantum dot antibody to the exosomes was further confirmed using similar methods. This demonstrates the potential for the use of a non-toxic conjugate to target nano-sized biomarkers that could be further used for the detection of different diseases.
Article 1 Read 0 Citations Conducting Copper(I/II)-Metallopolymer for the Electrocatalytic Oxygen Reduction Reaction (ORR) with High Kinetic Curren... Sait Elmas, Wesley Beelders, Xun Pan, Thomas Nann Published: 07 September 2018
Polymers, doi: 10.3390/polym10091002
DOI See at publisher website ABS Show/hide abstract
The oxygen reduction reaction (ORR) is still the most research-intensive aspect of a fuel cell. The sluggish kinetics of the electrocatalysts toward the ORR requires large amounts of platinum to be used as cathode material, which calls for alternatives to replace or minimize the amount of the noble metals used. This study describes the synthesis and complete characterization of a copper metallopolymer (Cu MP) based on a conducting polymer (CP) and single-site catalytic centers for the electrocatalytic ORR. The copper (II) catalyst, embedded in a redox-active and conducting polymeric environment, was pursued as a potential candidate to replace noble metals in fuel cell applications. Performance studies at a rotating disk electrode (RDE) showed that the metallopolymer exhibited a direct four-electron reduction at potentials between −150 and −350 mV vs. the reversible hydrogen electrode (RHE) and high kinetic current densities of over 22.62 mA/cm2. The kinetic current densities obtained at the Cu MP electrode outperformed most of the reported state-of-the art electrocatalysts toward the ORR. Further analysis of the Cu/CP hybrid revealed the copper being largely reduced to the oxidation state +I.
Article 4 Reads 0 Citations Electrospun Composites of Polycaprolactone and Porous Silicon Nanoparticles for the Tunable Delivery of Small Therapeuti... Steven J. P. McInnes, Thomas J. Macdonald, Ivan P. Parkin, T... Published: 29 March 2018
Nanomaterials, doi: 10.3390/nano8040205
DOI See at publisher website ABS Show/hide abstract
This report describes the use of an electrospun composite of poly(ε-caprolactone) (PCL) fibers and porous silicon (pSi) nanoparticles (NPs) as an effective system for the tunable delivery of camptothecin (CPT), a small therapeutic molecule. Both materials are biodegradable, abundant, low-cost, and most importantly, have no known cytotoxic effects. The composites were treated with and without sodium hydroxide (NaOH) to investigate the wettability of the porous network for drug release and cell viability measurements. CPT release and subsequent cell viability was also investigated. We observed that the cell death rate was not only affected by the addition of our CPT carrier, pSi, but also by increasing the rate of dissolution via treatment with NaOH. This is the first example of loading pSi NPs as a therapeutics nanocarrier into electronspun PCL fibers and this system opens up new possibilities for the delivery of molecular therapeutics.
Article 2 Reads 1 Citation Acetamide: a low-cost alternative to alkyl imidazolium chlorides for aluminium-ion batteries Nicolo Canever, Nicolas Bertrand, Thomas Nann Published: 01 January 2018
Chemical Communications, doi: 10.1039/c8cc04468f
DOI See at publisher website
Article 4 Reads 4 Citations Platinum Terpyridine Metallopolymer Electrode as Cost-Effective Replacement for Bulk Platinum Catalysts in Oxygen Reduct... Sait Elmas, Wesley Beelders, Siobhan J. Bradley, Renee Kroon... Published: 04 October 2017
ACS Sustainable Chemistry & Engineering, doi: 10.1021/acssuschemeng.7b02198
DOI See at publisher website
Article 4 Reads 1 Citation Electroactive Polyhydroquinone Coatings for Marine Fouling Prevention—A Rejected Dynamic pH Hypothesis and a Deceiving A... Mikael Larsson, Ali Yousefi, Sait Elmas, Johan B. Lindén, Th... Published: 21 August 2017
ACS Omega, doi: 10.1021/acsomega.7b00485
DOI See at publisher website
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