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Rodica Olar   Professor  University Lecturer 
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Rodica Olar published an article in October 2018.
Top co-authors See all
Mihaela Badea

47 shared publications

Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, Bucharest, Romania

Stefania Felicia Barbuceanu

19 shared publications

Organic Chemistry Department, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy

Valentina Uivarosi

17 shared publications

Department of General and Inorganic Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956 Bucharest, Romania

Constantin-Daniel Negut

16 shared publications

IRASM Radiation Processing Center, Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH), 30 Reactorului Str., P. O. Box MG-6, RO 077125 Bucharest Magurele, Ilfov, Romania, Tel.: +4021 404 2320, Fax: +4021 457 5331

Dana Marinescu

16 shared publications

University of Bucharest

27
Publications
5
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0
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133
Citations
Publication Record
Distribution of Articles published per year 
(2009 - 2018)
Total number of journals
published in
 
5
 
Publications See all
Article 0 Reads 0 Citations Spectral, thermal and biological characterization of complexes with a Schiff base bearing triazole moiety as potential a... Larisa Calu, Mihaela Badea, Nataša Čelan Korošin, Mariana Ca... Published: 31 October 2018
Journal of Thermal Analysis and Calorimetry, doi: 10.1007/s10973-018-7871-x
DOI See at publisher website
Article 0 Reads 0 Citations Thermal, spectral and biological characterisation of copper(II) complexes with isoniazid-based hydrazones Irina Zarafu, Mihaela Badea, Gabriela Ioniţă, Mariana Carmen... Published: 27 October 2018
Journal of Thermal Analysis and Calorimetry, doi: 10.1007/s10973-018-7853-z
DOI See at publisher website
Article 0 Reads 1 Citation Thermal behaviour of some biological active perchlorate complexes with a triazolopyrimidine derivative Mihaela Badea, Larisa Calu, Nataša Čelan Korošin, Iulia Gabr... Published: 06 March 2018
Journal of Thermal Analysis and Calorimetry, doi: 10.1007/s10973-018-7134-x
DOI See at publisher website
Article 2 Reads 3 Citations Synthesis, Structural Characterization, Antimicrobial Activity, and In Vitro Biocompatibility of New Unsaturated Carboxy... Gina Vasile Scăețeanu, Mariana Carmen Chifiriuc, Coralia Ble... Published: 12 January 2018
Molecules, doi: 10.3390/molecules23010157
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
The synthesis, structural characterization, cytotoxicity, and antimicrobial properties of four new complexes formed by employing acrylate anion and 2,2′-bipyridine are reported herein. X-ray crystallography revealed the trinuclear nature of [Mn3(2,2′-bipy)2(C3H3O2)6] (1), meanwhile complexes with general formula [M(2,2′-bipy)(C3H3O2)2(H2O)x]∙yH2O ((2) M: Ni, x = 1, y = 0; (3) M: Cu, x = 1, y = 0; (4) M: Zn, x = 0, y = 1; 2,2′-bipy: 2,2′-bipyridine; C3H3O2: acrylate anion) were shown to be mononuclear. The lowest minimum inhibitory concentration (MIC) of 128 μg mL−1 was recorded for all four tested complexes against Candida albicans, for complex (3) against Escherichia coli, and for complex (4) against Staphylocococcus aureus. Compounds (3) and (4) were also potent efflux pumps activity inhibitors (EPI), proving their potential for use in synergistic combinations with antibiotics. Complexes (1)–(4) revealed that they were not cytotoxic to HCT-8 cells. They also proved to interfere with the cellular cycle of tumour HCT-8 cells by increasing the number of cells found in the S and G2/M phases. Taken together, these results demonstrate the potential of zinc and copper complexes for use in the development of novel antimicrobial and anti-proliferative agents.
BOOK-CHAPTER 0 Reads 1 Citation Nanoformulation as a Tool for Improve the Pharmacological Profile of Platinum and Ruthenium Anticancer Drugs Valentina Uivarosi, Rodica Olar, Mihaela Badea Published: 23 August 2017
Descriptive Inorganic Chemistry Researches of Metal Compounds, doi: 10.5772/intechopen.68306
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Article 0 Reads 2 Citations Synthesis and Structural Investigation of New Bio-Relevant Complexes of Lanthanides with 5-Hydroxyflavone: DNA Binding a... Alexandra-Cristina Munteanu, Mihaela Badea, Rodica Olar, Lui... Published: 16 December 2016
Molecules, doi: 10.3390/molecules21121737
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
In the present work, we attempted to develop new metal coordination complexes of the natural flavonoid 5-hydroxyflavone with Sm(III), Eu(III), Gd(III), Tb(III). The resultant hydroxo complexes have been characterized by a variety of spectroscopic techniques, including fluorescence, FT-IR, UV-Vis, EPR and mass spectral studies. The general chemical formula of the complexes is [Ln(C15H9O3)3(OH)2(H2O)x]·nH2O, where Ln is the lanthanide cation and x = 0 for Sm(III), x = 1 for Eu(III), Gd(III), Tb(III) and n = 0 for Sm(III), Gd(III), Tb(III), n = 1 for Eu(III), respectively. The proposed structures of the complexes were optimized by DFT calculations. Theoretical calculations and experimental determinations sustain the proposed structures of the hydroxo complexes, with two molecules of 5-hydroxyflavone acting as monoanionic bidentate chelate ligands. The interaction of the complexes with calf thymus DNA has been explored by fluorescence titration and UV-Vis absorption binding studies, and revealed that the synthesized complexes interact with DNA with binding constants (Kb) ~ 104. Human serum albumin (HSA) and transferrin (Tf) binding studies have also been performed by fluorescence titration techniques (fluorescence quenching studies, synchronous fluorescence spectra). The apparent association constants (Ka) and thermodynamic parameters have been calculated from the fluorescence quenching experiment at 299 K, 308 K, and 318 K. The quenching curves indicate that the complexes bind to HSA with smaller affinity than the ligand, but to Tf with higher binding affinities than the ligand.
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