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Peter Meikle   Dr.  Other 
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Peter Meikle published an article in February 2019.
Top co-authors See all
Andrew J. Saykin

716 shared publications

Indiana University School of Medicine and Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, USA

Oliver Fiehn

271 shared publications

West Coast Metabolomics Center, University of California, Davis, One Shields Avenue, Davis, California 95616, United States

Jonathan Golledge

239 shared publications

Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry; James Cook University; Townsville Queensland Australia

Reinald Pamplona

217 shared publications

Experimental Medicine Department. IRBLleida, University of Lleida, 25198 Lleida, Spain

Jose Viña

204 shared publications

Freshage Research Group- Department of Physiology, Faculty of Medicine, University of Valencia, Avenida Blasco Ibañez 15, CIBERFES, INCLIVA, 46010 Valencia, Spain

36
Publications
24
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0
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216
Citations
Publication Record
Distribution of Articles published per year 
(2008 - 2019)
Total number of journals
published in
 
27
 
Publications See all
PREPRINT-CONTENT 0 Reads 0 Citations Sets of Co-regulated Serum Lipids are Associated with Alzheimer Disease Pathophysiology Dinesh K Barupal, Rebecca Bailli, Sili Fan, Andrew J Saykin,... Published: 18 February 2019
bioRxiv, doi: 10.1101/550723
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INTRODUCTION: Altered regulation of lipid metabolism in Alzheimer disease (AD) can be characterized using lipidomic profiling. METHOD: 341 serum lipids were measured in 806 participants enrolled in the Alzheimer Disease Neuroimaging Initiative Phase 1 (ADNI1) cohort and analysed using lipid regression models and lipid set enrichment statistics. RESULTS: AD diagnosis was associated with 7 of 28 lipid sets of which four also correlated with cognitive decline, including polyunsaturated fatty acids. CSF amyloid beta Aβ1-42 correlated with glucosylceramides, lysophosphatidyl cholines and unsaturated triacylglycerides; CSF total tau and brain atrophy correlated with monounsaturated sphingomyelins and ceramides, in addition to EPA-containing lipids. DISCUSSION: Lipid desaturation, elongation and acyl chain remodeling are dysregulated across the spectrum of AD pathogenesis. Monounsaturated lipids were important in early stages of AD, while polyunsaturated lipid metabolism was associated with later stages of AD.
Article 0 Reads 0 Citations Exceptional human longevity is associated with a specific plasma phenotype of ether lipids I. Pradas, M. Jové, K. Huynh, J. Puig, M. Ingles, C. Borras,... Published: 29 January 2019
Redox Biology, doi: 10.1016/j.redox.2019.101127
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A lipid profile resistant to oxidative damage is an inherent trait associated with animal lifespan. However, there is a lack of lipidomic studies on human longevity. Here we use mass spectrometry based technologies to detect and quantify 137 ether lipids to define a phenotype of healthy humans with exceptional lifespan. Ether lipids were chosen because of their antioxidant properties and ability to modulate oxidative stress. Our results demonstrate that a specific ether lipid signature can be obtained to define the centenarian state. This profile comprises higher level of alkyl forms derived from phosphatidylcholine with shorter number of carbon atoms and double bonds; and decreased content in alkenyl forms from phosphatidylethanolamine with longer chain length and higher double bonds. This compositional pattern suggests that ether lipids from centenarians are more resistant to lipid peroxidation, and that ether lipid signature expresses an optimized feature associated with exceptional human longevity. These results are in keeping with the free radical theory of aging.
Article 0 Reads 1 Citation High-Throughput Plasma Lipidomics: Detailed Mapping of the Associations with Cardiometabolic Risk Factors Kevin Huynh, Christopher K. Barlow, Kaushala S. Jayawardana,... Published: 01 January 2019
Cell Chemical Biology, doi: 10.1016/j.chembiol.2018.10.008
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Article 0 Reads 0 Citations Brown adipose tissue and lipid metabolism: New strategies for identification of activators and biomarkers with clinical ... Angie S. Xiang, Peter J. Meikle, Andrew L. Carey, Bronwyn A.... Published: 01 December 2018
Pharmacology & Therapeutics, doi: 10.1016/j.pharmthera.2018.07.002
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Article 2 Reads 0 Citations Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potentia... Yow Keat Tham, Bianca C. Bernardo, Kevin Huynh, Jenny Y.Y. O... Published: 01 September 2018
Cell Reports, doi: 10.1016/j.celrep.2018.08.017
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Article 0 Reads 0 Citations Lipidomics Reveals a Tissue-Specific Fingerprint Irene Pradas, Kevin Huynh, Rosanna Cabré, Victòria Ayala, Pe... Published: 28 August 2018
Frontiers in Physiology, doi: 10.3389/fphys.2018.01165
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In biological systems lipids generate membranes and have a key role in cell signaling and energy storage. Therefore, there is a wide diversity of molecular lipid expressed at the compositional level in cell membranes and organelles, as well as in tissues, whose lipid distribution remains unclear. Here, we report a mass spectrometry study of lipid abundance across 7 rat tissues, detecting and quantifying 652 lipid molecular species from the glycerolipid, glycerophospholipid, fatty acyl, sphingolipid, sterol lipid and prenol lipid categories. Our results demonstrate that every tissue analyzed presents a specific lipid distribution and concentration. Thus, glycerophospholipids are the most abundant tissue lipid, they share a similar tissue distribution but differ in particular lipid species between tissues. Sphingolipids are more concentrated in the renal cortex and sterol lipids can be found mainly in both liver and kidney. Both types of white adipose tissue, visceral and subcutaneous, are rich in glycerolipids but differing the amount. Acylcarnitines are mainly in the skeletal muscle, gluteus and soleus, while heart presents higher levels of ubiquinone than other tissues. The present study demonstrates the existence of a rat tissue-specific fingerprint.
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