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Peter Meikle   Dr.  Other 
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Peter Meikle published an article in September 2018.
Top co-authors See all
Melanie Bahlo

108 shared publications

Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

Douglas J. Hilton

102 shared publications

Division of Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia

Jonathan Golledge

94 shared publications

Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia

John C. L. Mamo

75 shared publications

School of Public Health, Curtin Health Innovation Research Institute, Curtin University, Perth, Australia

Maria Fuller

63 shared publications

School of Medicine; University of Adelaide; Adelaide South Australia Australia

13
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15
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104
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Publication Record
Distribution of Articles published per year 
(2008 - 2018)
Total number of journals
published in
 
8
 
Publications See all
Article 0 Reads 0 Citations Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potentia... Yow Keat Tham, Bianca C. Bernardo, Kevin Huynh, Jenny Y.Y. O... Published: 01 September 2018
Cell Reports, doi: 10.1016/j.celrep.2018.08.017
DOI See at publisher website
Article 2 Reads 0 Citations Weight Loss and Exercise Alter the High-Density Lipoprotein Lipidome and Improve High-Density Lipoprotein Functionality ... Anmar A. Khan, Piyushkumar A. Mundra, Nora E. Straznicky, Pa... Published: 28 December 2017
Arteriosclerosis, Thrombosis, and Vascular Biology, doi: 10.1161/atvbaha.117.310212
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Article 4 Reads 1 Citation Baseline serum phosphatidylcholine plasmalogen concentrations are inversely associated with incident myocardial infarcti... Joseph V. Moxon, Rhondda E. Jones, Gerard Wong, Jacquelyn M.... Published: 01 August 2017
Atherosclerosis, doi: 10.1016/j.atherosclerosis.2017.06.925
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Article 2 Reads 4 Citations Lipidomic Profiles in Diabetes and Dementia Kevin Huynh, Ralph N. Martins, Peter J. Meikle Published: 17 July 2017
Journal of Alzheimer's Disease, doi: 10.3233/JAD-161215
DOI See at publisher website
Article 2 Reads 1 Citation The Effects of Long-Term Saturated Fat Enriched Diets on the Brain Lipidome Corey Giles, Ryusuke Takechi, Natalie A. Mellett, Peter J. M... Published: 01 December 2016
PLOS ONE, doi: 10.1371/journal.pone.0166964
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The brain is highly enriched in lipids, where they influence neurotransmission, synaptic plasticity and inflammation. Non-pathological modulation of the brain lipidome has not been previously reported and few studies have investigated the interplay between plasma lipid homeostasis relative to cerebral lipids. This study explored whether changes in plasma lipids induced by chronic consumption of a well-tolerated diet enriched in saturated fatty acids (SFA) was associated with parallel changes in cerebral lipid homeostasis. Male C57Bl/6 mice were fed regular chow or the SFA diet for six months. Plasma, hippocampus (HPF) and cerebral cortex (CTX) lipids were analysed by LC-ESI-MS/MS. A total of 348 lipid species were determined, comprising 25 lipid classes. The general abundance of HPF and CTX lipids was comparable in SFA fed mice versus controls, despite substantial differences in plasma lipid-class abundance. However, significant differences in 50 specific lipid species were identified as a consequence of SFA treatment, restricted to phosphatidylcholine (PC), phosphatidylethanolamine (PE), alkyl-PC, alkenyl-PC, alkyl-PE, alkenyl-PE, cholesterol ester (CE), diacylglycerol (DG), phosphatidylinositol (PI) and phosphatidylserine (PS) classes. Partial least squares regression of the HPF/CTX lipidome versus plasma lipidome revealed the plasma lipidome could account for a substantial proportion of variation. The findings demonstrate that cerebral abundance of specific lipid species is strongly associated with plasma lipid homeostasis.
Article 2 Reads 1 Citation cAMP Response Element Binding Protein1 Is Essential for Activation of Steroyl Co-Enzyme A Desaturase 1 (Scd1) in Mouse L... Nisha Antony, Jacqui R. Weir, Annie R. A. McDougall, Anthony... Published: 18 April 2013
PLOS ONE, doi: 10.1371/journal.pone.0059763
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Cyclic AMP Response Element-Binding Protein 1 (Creb1) is a transcription factor that mediates cyclic adenosine 3′, 5′-monophosphate (cAMP) signalling in many tissues. Creb1−/− mice die at birth due to respiratory failure and previous genome-wide microarray analysis of E17.5 Creb1−/− fetal mouse lung identified important Creb1-regulated gene targets during lung development. The lipogenic enzymes stearoyl-CoA desaturase 1 (Scd1) and fatty acid synthase (Fasn) showed highly reduced gene expression in Creb1−/− lungs. We therefore hypothesized that Creb1 plays a crucial role in the transcriptional regulation of genes involved in pulmonary lipid biosynthetic pathways during lung development. In this study we confirmed that Scd1 and Fasn mRNA levels were down regulated in the E17.5 Creb1−/− mouse lung while the lipogenic-associated transcription factors SrebpF1, C/ebpα and Pparγ were increased. In vivo studies using germline (Creb1−/−) and lung epithelial-specific (Creb1EpiΔ/Δ) Creb1 knockout mice showed strongly reduced Scd1, but not Fasn gene expression and protein levels in lung epithelial cells. In vitro studies using mouse MLE-15 epithelial cells showed that forskolin-mediated activation of Creb1 increased both Scd1 gene expression and protein synthesis. Additionally, MLE15 cells transfected with a dominant-negative ACreb vector blocked forskolin-mediated stimulation of Scd1 gene expression. Lipid profiling in MLE15 cells showed that dominant-negative ACreb suppressed forskolin-induced desaturation of ether linked lipids to produce plasmalogens, as well as levels of phosphatidylethanolamine, ceramide and lysophosphatidylcholine. Taken together these results demonstrate that Creb1 is essential for the induction and maintenance of Scd1 in developing fetal mouse lung epithelial cells.
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