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DUANGJAI TUNGMUNNITHUM   Dr.  University Lecturer 
Affiliations
Department of Pharmaceutical Botany, Faculty of Pharmacy, Mahidol University, Bangkok, THAILAND
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DUANGJAI TUNGMUNNITHUM published an article in April 2019.
Research Keywords & Expertise
0 Anti-aging
0 Nanotechnology
0 antioxidant
0 flavonoids
0 phenolic acid
0 medicinal plants
Top co-authors See all
Bilal Haider Abbasi

161 shared publications

Department of Biotechnology, Quaid-i-Azam University, Islamabad 45320, Pakistan

François Mesnard

26 shared publications

BIOPI - EA 3900, Univ. Picardie Jules Verne, Amiens Cedex, France

Sullivan Renouard

21 shared publications

Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC) EA1207 INRA USC1328, Plant LIGNANS Team, Université d’Orléans, 28000 Chartres, France;(L.G.);(S.D.);(C.C.);(C.D.);(T.F.);(J.L.d.L.);(E.A.L.);(S.R.);(D.T.);(J.D.);(B.H.A.);(É.L.)

Ophélie Fliniaux

19 shared publications

Biologie des Plantes et Innovation (BIOPI) EA 3900, Université de Picardie Jules Verne, 80000 Amiens, France;(O.F.);(F.M.)

Cyrielle Corbin

18 shared publications

Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC) EA1207 INRA USC1328, Plant LIGNANS Team, Université d’Orléans, 28000 Chartres, France;(L.G.);(S.D.);(C.C.);(C.D.);(T.F.);(J.L.d.L.);(E.A.L.);(S.R.);(D.T.);(J.D.);(B.H.A.);(É.L.)

13
Publications
2
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12
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Publication Record
Distribution of Articles published per year 
(2016 - 2019)
Total number of journals
published in
 
8
 
Publications See all
Article 0 Reads 0 Citations Effect of Ultraviolet-C Radiation and Melatonin Stress on Biosynthesis of Antioxidant and Antidiabetic Metabolites Produ... Muhammad Asad Ullah, Duangjai Tungmunnithum, Laurine Garros,... Published: 11 April 2019
International Journal of Molecular Sciences, doi: 10.3390/ijms20071787
DOI See at publisher website ABS Show/hide abstract
Lepidium sativum L. is a rich source of polyphenols that have huge medicinal and pharmaceutical applications. In the current study, an effective abiotic elicitation strategy was designed for enhanced biosynthesis of polyphenols in callus culture of L. sativum. Callus was exposed to UV-C radiations for different time intervals and various concentrations of melatonin. Secondary metabolites were quantified by using high-performance liquid chromatography (HPLC). Results indicated the total secondary metabolite accumulation of nine quantified compounds was almost three fold higher (36.36 mg/g dry weight (DW)) in melatonin (20 μM) treated cultures, whereas, in response to UV-C (60 min), a 2.5 fold increase (32.33 mg/g DW) was recorded compared to control (13.94 mg/g DW). Metabolic profiling revealed the presence of three major phytochemicals, i.e., chlorogenic acid, kaemferol, and quercetin, in callus culture of L. sativum. Furthermore, antioxidant, antidiabetic, and enzymatic activities of callus cultures were significantly enhanced. Maximum antidiabetic activities (α-glucosidase: 57.84%; α-amylase: 62.66%) were recorded in melatonin (20 μM) treated callus cultures. Overall, melatonin proved to be an effect elicitor compared to UV-C and a positive correlation in these biological activities and phytochemical accumulation was observed. The present study provides a better comparison of both elicitors and their role in the initiation of physiological pathways for enhanced metabolites biosynthesis in vitro callus culture of L. sativum.
Article 0 Reads 0 Citations Interactive Effects of Light and Melatonin on Biosynthesis of Silymarin and Anti-Inflammatory Potential in Callus Cultur... Muzamil Shah, Muhammad Asad Ullah, Samantha Drouet, Muhammad... Published: 27 March 2019
Molecules, doi: 10.3390/molecules24071207
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Silybum marianum (L.) Gaertn. is a well-known medicinal herb, primarily used in liver protection. Light strongly affects several physiological processes along with secondary metabolites biosynthesis in plants. Herein, S. marianum was exploited for in vitro potential under different light regimes in the presence of melatonin. The optimal callogenic response occurred in the combination of 1.0 mg/L α-naphthalene acetic acid and 0.5 mg/L 6-benzylaminopurine under photoperiod. Continuous light associated with melatonin treatment increased total flavonoid content (TFC), total phenolic content (TPC) and antioxidant potential, followed by photoperiod and dark treatments. The increased level of melatonin has a synergistic effect on biomass accumulation under continuous light and photoperiod, while an adverse effect was observed under dark conditions. More detailed phytochemical analysis showed maximum total silymarin content (11.92 mg/g dry weight (DW)) when placed under continuous light + 1.0 mg/L melatonin. Individually, the level of silybins (A and B), silydianin, isolsilychristin and silychristin was found highest under continuous light. Anti-inflammatory activities were also studied and highest percent inhibition was recorded against 15-lipoxygenase (15-LOX) for cultures cultivated under continuous light (42.33%). The current study helps us to better understand the influence of melatonin and different light regimes on silymarin production as well as antioxidant and anti-inflammatory activities in S. marianum callus extracts.
PREPRINT 0 Reads 0 Citations Interactive Effects of Light and Melatonin on Biosynthesis of Silymarin and Anti-inflammatory Potential in Callus Cultur... Muzamil Shah, Muhammad Asad Ullah, Samantha Drouet, Muhammad... Published: 01 March 2019
doi: 10.20944/preprints201903.0007.v1
DOI See at publisher website ABS Show/hide abstract
Silybum marianum L. is a well-known medicinal herb, primarily used in liver protection. Light strongly affects several physiological processes along with secondary metabolites biosynthesis in plants. Herein, S. marianum was exploited for in vitro potential under different light regimes in the presence of melatonin. The optimum callogenic response occurred in combination of 1.0 mg/L α-naphthalene acetic acid and 0.5 mg/L 6-Benzylaminopurine under photoperiod. Continuous light associated with melatonin treatment increased total flavonoid content (TFC), total phenolic content (TPC) and antioxidant potential, followed by photoperiod and dark treatments. The increased level of melatonin has a synergistic effect on biomass accumulation under continuous light and photoperiod, while adverse effect was observed under dark condition. More detailed phytochemical analysis showed maximum total silymarin content (11.92 mg/g DW) when placed under continuous light + 1.0 mg/L melatonin. Individually, the level of silybins (A and B), silydianin, isolsilychristin and silychristin was found highest under continuous light. Anti-inflammatory activities were also studied and highest percent inhibition was recorded against 15-LOX for cultures cultivated under continuous light (42.33%). The current study helps to better understand the influence of melatonin and different light regimes on silymarin production as well as antioxidant and anti-inflammatory activities in S. marianum callus extracts.
Article 1 Read 0 Citations Green Ultrasound Assisted Extraction of trans Rosmarinic Acid from Plectranthus scutellarioides (L.) R.Br. Leaves Duangjai Tungmunnithum, Laurine Garros, Samantha Drouet, Sul... Published: 27 February 2019
Plants, doi: 10.3390/plants8030050
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Painted nettle (Plectranthus scutellarioides (L.) R.Br.) is an ornamental plant belonging to Lamiaceae family, native of Asia. Its leaves constitute one of the richest sources of trans-rosmarinic acid, a well-known antioxidant and antimicrobial phenolic compound. These biological activities attract interest from the cosmetic industry and the demand for the development of green sustainable extraction processes. Here, we report on the optimization and validation of an ultrasound-assisted extraction (USAE) method using ethanol as solvent. Following preliminary single factor experiments, the identified limiting extraction parameters (i.e., ultrasound frequency, extraction duration, and ethanol concentration) were further optimized using a full factorial design approach. The method was then validated following the recommendations of the association of analytical communities (AOAC) to ensure the precision and accuracy of the method used to quantify trans-rosmarinic acid. Highest trans-rosmarinic acid content was obtained using pure ethanol as extraction solvent following a 45-minute extraction in an ultrasound bath operating at an ultrasound frequency of 30 kHz. The antioxidant (in vitro radical scavenging activity) and antimicrobial (directed toward Staphylococcus aureus ACTT6538) activities were significantly correlated with the trans-rosmarinic acid concentration of the extract evidencing that these key biological activities were retained following the extraction using this validated method. Under these conditions, 110.8 mg/g DW of trans-rosmarinic acid were extracted from lyophilized P. scutellarioides leaves as starting material evidencing the great potential of this renewable material for cosmetic applications. Comparison to other classical extraction methods evidenced a clear benefit of the present USAE method both in terms of yield and extraction duration.
Article 0 Reads 0 Citations Differential Production of Phenylpropanoid Metabolites in Callus Cultures of Ocimum basilicum L. with Distinct In Vitro ... Munazza Nazir, Duangjai Tungmunnithum, Shankhamala Bose, Sam... Published: 25 January 2019
Journal of Agricultural and Food Chemistry, doi: 10.1021/acs.jafc.8b05647
DOI See at publisher website
Article 1 Read 0 Citations Isodon rugosus (Wall. ex Benth.) Codd In Vitro Cultures: Establishment, Phytochemical Characterization and In Vitro Anti... Bilal Haider Abbasi, Aisha Siddiquah, Duangjai Tungmunnithum... Published: 21 January 2019
International Journal of Molecular Sciences, doi: 10.3390/ijms20020452
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Isodon rugosus (Wall. ex Benth.) Codd accumulates large amounts of phenolics and pentacyclic triterpenes. The present study deals with the in vitro callus induction from stem and leaf explants of I. rugosus under various plant growth regulators (PGRs) for the production of antioxidant and anti-ageing compounds. Among all the tested PGRs, thidiazuron (TDZ) used alone or in conjunction with α-napthalene acetic acid (NAA) induced highest callogenesis in stem-derived explants, as compared to leaf-derived explants. Stem-derived callus culture displayed maximum total phenolic content and antioxidant activity under optimum hormonal combination (3.0 mg/L TDZ + 1.0 mg/L NAA). HPLC analysis revealed the presence of plectranthoic acid (373.92 µg/g DW), oleanolic acid (287.58 µg/g DW), betulinic acid (90.51 µg/g DW), caffeic acid (91.71 µg/g DW), and rosmarinic acid (1732.61 µg/g DW). Complete antioxidant and anti-aging potential of extracts with very contrasting phytochemical profiles were investigated. Correlation analyses revealed rosmarinic acid as the main contributor for antioxidant activity and anti-aging hyaluronidase, advance glycation end-products inhibitions and SIRT1 activation, whereas, pentacyclic triterpenoids were correlated with elastase, collagenase, and tyrosinase inhibitions. Altogether, these results clearly evidenced the great valorization potential of I. rugosus calli for the production of antioxidant and anti-aging bioactive extracts for cosmetic applications.
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