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Dan Mihailescu  - - - 
Top co-authors See all
Mihai V. Putz

93 shared publications

Laboratory of Structural and Computational Physical-Chemistry for Nanosciences and QSAR, Biology-Chemistry Department, West University of Timisoara, Pestalozzi Street No. 44, Timisoara, RO-300115, Romania

Cătălin Buiu

36 shared publications

Department of Automatic Control and Systems Engineering, Politehnica University of Bucharest, Bucharest, Romania

Traian Dascalu

30 shared publications

National Institute for Laser, Plasma and Radiation Physics, Laboratory of Solid-State Quantum Electronics, Bucharest 077125, Romania

Adina-Luminita Milac

28 shared publications

Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania

Maria Mernea

26 shared publications

Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania

6
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Publication Record
Distribution of Articles published per year 
(2011 - 2017)
Total number of journals
published in
 
4
 
Publications
BOOK-CHAPTER 3 Reads 0 Citations Radiation Induced Molecular Damage Addressed by Terahertz Spectroscopy – A Theoretical Study M. Mernea, O. Calborean, I. Vasile, S. Avram, D. F. Mihailes... Published: 03 August 2017
NATO Science for Peace and Security Series B: Physics and Biophysics, doi: 10.1007/978-94-024-1093-8_6
DOI See at publisher website
Conference 0 Reads 0 Citations LEARNING IS IN THE EMOTIONS OF THE BEHOLDER - FEATURES OF THE IDEAL PROFESSOR C. Strungaru, F. Oprina, L. Petrescu, S. Avram, D. F. Mihail... Published: 01 March 2016
INTED2016 Proceedings, doi: 10.21125/inted.2016.2027
DOI See at publisher website
Article 0 Reads 1 Citation In vitro human serum albumin glycation monitored by Terahertz spectroscopy Maria Mernea, Alina Ionescu, Ionut Vasile, Cristina Nica, Gh... Published: 12 February 2015
Optical and Quantum Electronics, doi: 10.1007/s11082-015-0129-y
DOI See at publisher website
Article 0 Reads 2 Citations Structure–Biological Function Relationship Extended to Mitotic Arrest-Deficient 2-Like Protein Mad2 Native and Mutants-N... Speranta Avram, Adina-Luminita Milac, Maria Mernea, Dan Miha... Published: 18 November 2014
International Journal of Molecular Sciences, doi: 10.3390/ijms151121381
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Overexpression of mitotic arrest-deficient proteins Mad1 and Mad2, two components of spindle assembly checkpoint, is a risk factor for chromosomal instability (CIN) and a trigger of many genetic disorders. Mad2 transition from inactive open (O-Mad2) to active closed (C-Mad2) conformations or Mad2 binding to specific partners (cell-division cycle protein 20 (Cdc20) or Mad1) were targets of previous pharmacogenomics studies. Here, Mad2 binding to Cdc20 and the interconversion rate from open to closed Mad2 were predicted and the molecular features with a critical contribution to these processes were determined by extending the quantitative structure-activity relationship (QSAR) method to large-size proteins such as Mad2. QSAR models were built based on available published data on 23 Mad2 mutants inducing CIN-related functional changes. The most relevant descriptors identified for predicting Mad2 native and mutants action mechanism and their involvement in genetic disorders are the steric (van der Waals area and solvent accessible area and their subdivided) and energetic van der Waals energy descriptors. The reliability of our QSAR models is indicated by significant values of statistical coefficients: Cross-validated correlation q² (0.53–0.65) and fitted correlation r² (0.82–0.90). Moreover, based on established QSAR equations, we rationally design and analyze nine de novo Mad2 mutants as possible promoters of CIN.
Article 0 Reads 4 Citations Validation of protein structural models using THz spectroscopy: a promising approach to solve three-dimensional structur... Maria Mernea, Octavian Calborean, Oana Grigore, Traian Dasca... Published: 18 January 2014
Optical and Quantum Electronics, doi: 10.1007/s11082-013-9872-0
DOI See at publisher website
BOOK-CHAPTER 2 Reads 0 Citations Bovine Serum Albumin 3D Structure Determination by THz Spectroscopy and Molecular Modeling Maria Mernea, Aurel Leca, Traian Dascalu, Dan Mihailescu Published: 22 January 2011
NATO Science for Peace and Security Series B: Physics and Biophysics, doi: 10.1007/978-94-007-0769-6_14
DOI See at publisher website
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