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Stefan Günther  - - - 
Top co-authors See all
Manfred Jung

168 shared publications

Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104 Freiburg, Germany

Fidele Ntie-Kang

49 shared publications

Department of Pharmaceutical Chemistry, Martin-Luther University of Halle-Wittenberg, Halle (Saale), Germany

Irmgard Merfort

44 shared publications

Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-University Freiburg, Freiburg, Germany

Björn Grüning

39 shared publications

University of Freiburg, Department of Computer Science, Freiburg, Germany

Steffen U. Eisenhardt

23 shared publications

Universitätsklinikum Freiburg, Klinik für Plastische und Handchirurgie

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Publication Record
Distribution of Articles published per year 
(2011 - 2018)
Total number of journals
published in
 
11
 
Publications See all
Article 1 Read 0 Citations Bromodomain Drug Discovery – the Past, the Present, and the Future Mehrosh Pervaiz, Pankaj Mishra, Stefan Günther Published: 05 October 2018
The Chemical Record, doi: 10.1002/tcr.201800074
DOI See at publisher website
Article 0 Reads 1 Citation New insights into the structural dynamics of the kinase JNK3. Pankaj Mishra, Stefan Günther Published: 21 June 2018
Scientific Reports, doi: 10.1038/s41598-018-27867-3
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
In this work, we study the dynamics and the energetics of the all-atom structure of a neuronal-specific serine/threonine kinase c-Jun N-terminal kinase 3 (JNK3) in three states: unphosphorylated, phosphorylated, and ATP-bound phosphorylated. A series of 2 µs atomistic simulations followed by a conformational landscape mapping and a principal component analysis supports the mechanistic understanding of the JNK3 inactivation/activation process and also indicates key structural intermediates. Our analysis reveals that the unphosphorylated JNK3 undergoes the 'open-to-closed' movement via a two-step mechanism. Furthermore, the phosphorylation and ATP-binding allow the JNK3 kinase to attain a fully active conformation. JNK3 is a widely studied target for small-drugs used to treat a variety of neurological disorders. We believe that the mechanistic understanding of the large-conformational changes upon the activation of JNK3 will aid the development of novel targeted therapeutics.
Conference 21 Reads 0 Citations Mitochondrial metabolomics reveals compartment-specific metabolic responses in yeast cells Daqiang Pan, Caroline Lindau, Simon Lagies, Stefan Günther, ... Published: 20 November 2017
The 2nd International Electronic Conference on Metabolomics, doi: 10.3390/iecm-2-04981
DOI See at publisher website
Article 0 Reads 0 Citations Disease relevant modifications of the methylome and transcriptome by particulate matter (PM2.5) from biomass combustion Katharina Heßelbach, Gwang-Jin Kim, Stephan Flemming, Thomas... Published: 02 September 2017
Epigenetics, doi: 10.1080/15592294.2017.1356555
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Exposure to particulate matter (PM) is recognized as a major health hazard, but molecular responses are still insufficiently described. We analyzed the epigenetic impact of ambient PM2.5 from biomass combustion on the methylome of primary human bronchial epithelial BEAS-2B cells using the Illumina HumanMethylation450 BeadChip. The transcriptome was determined by the Affymetrix HG-U133 Plus 2.0 Array. PM2.5 induced genome wide alterations of the DNA methylation pattern, including differentially methylated CpGs in the promoter region associated with CpG islands. Gene ontology analysis revealed that differentially methylated genes were significantly clustered in pathways associated with the extracellular matrix, cellular adhesion, function of GTPases, and responses to extracellular stimuli, or were involved in ion binding and shuttling. Differential methylations also affected tandem repeats. Additionally, 45 different miRNA CpG loci showed differential DNA methylation, most of them proximal to their promoter. These miRNAs are functionally relevant for lung cancer, inflammation, asthma, and other PM-associated diseases. Correlation of the methylome and transcriptome demonstrated a clear bias toward transcriptional activation by hypomethylation. Genes that exhibited both differential methylation and expression were functionally linked to cytokine and immune responses, cellular motility, angiogenesis, inflammation, wound healing, cell growth, differentiation and development, or responses to exogenous matter. Disease ontology of differentially methylated and expressed genes indicated their prominent role in lung cancer and their participation in dominant cancer related signaling pathways. Thus, in lung epithelial cells, PM2.5 alters the methylome of genes and noncoding transcripts or elements that might be relevant for PM- and lung-associated diseases.
Article 0 Reads 6 Citations NANPDB: A Resource for Natural Products from Northern African Sources Fidele Ntie-Kang, Kiran K. Telukunta, Kersten Döring, Conrad... Published: 22 June 2017
Journal of Natural Products, doi: 10.1021/acs.jnatprod.7b00283
DOI See at publisher website PubMed View at PubMed
Article 0 Reads 3 Citations SeMPI: a genome-based secondary metabolite prediction and identification web server Paul F. Zierep, Natàlia Padilla, Dimitar G. Yonchev, Kiran K... Published: 27 April 2017
Nucleic Acids Research, doi: 10.1093/nar/gkx289
DOI See at publisher website
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