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Neena Capalash  - - - 
Top co-authors See all
Ashok Kumar

168 shared publications

Ravinder Kumar

127 shared publications

Panjab University

Richa Gupta

104 shared publications

Panjab University

Kusum Harjai

68 shared publications

Panjab University Department of Microbiology Chandigarh India

Ram A. Vishwakarma

63 shared publications

22
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Publication Record
Distribution of Articles published per year 
(2001 - 2017)
Total number of journals
published in
 
19
 
Publications See all
Conference 4 Reads 0 Citations Metabolic shifts associated with postharvest storage of Kinnow (Citrus reticulata). Manpreet Kaur Saini, Neena Capalash, Sukhvinder Pal Singh, C... Published: 20 November 2017
The 2nd International Electronic Conference on Metabolomics, doi: 10.3390/iecm-2-04984
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Article 0 Reads 0 Citations Exploring Derivatives of Quinazoline Alkaloid l -Vasicine as Cap Groups in the Design and Biological Mechanistic Evaluat... Mudassier Ahmad, Mushtaq A. Aga, Javeed Ahmad Bhat, Abdul Ro... Published: 13 April 2017
Journal of Medicinal Chemistry, doi: 10.1021/acs.jmedchem.7b00322
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L-Vasicine is a quinazoline alkaloid with electron dense ring and additional functionalities in its structure. Employing target oriented synthesis (TOS) based on in silico studies, molecules with significant docking scores containing different derivatives of l-vasicine as caps were synthesized. Interestingly, one molecule i.e., 4a which contained 3-hyroxypyrrolidine as a cap group and six carbon long aliphatic chain as a linker was found to inhibit HDACs. 4a showed more specificity towards class I HDAC isoforms. Also 4a was found to be less cytotoxic towards normal cell lines as compared to cancer cell lines. 4a inhibited cancer cell growth and induced cell death by various mechanisms. However, 4a was found to induce cell death independent of ROS generation and unlike many natural product based HDAC inhibitors, 4a was found to be non-toxic under in vivo conditions. Importantly, we for the first time report the possibility of using 3-hydroxypyrrolidine a cap for the synthesis of HDAC inhibitors with good potency.
Article 0 Reads 3 Citations UHRF1: The key regulator of epigenetics and molecular target for cancer therapeutics Harsimran Sidhu, Neena Capalash Published: 01 February 2017
Tumor Biology, doi: 10.1177/1010428317692205
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BOOK-CHAPTER 0 Reads 0 Citations Quorum Sensing in Pseudomonas aeruginosa: Mechanism and Regulation of Virulence Sajal Sarabhai, Amanjot Kaur, Neena Capalash, Prince Sharma Published: 01 January 2016
Pseudomonas: Molecular and Applied Biology, doi: 10.1007/978-3-319-31198-2_6
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Article 0 Reads 2 Citations Recent advances in immunosensor for narcotic drug detection Sonu Gandhi, Pankaj Suman, ASHOK KUMAR, Prince Sharma, Neena... Published: 28 December 2015
BioImpacts, doi: 10.15171/bi.2015.30
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Immunosensor for illicit drugs have gained immense interest and have found several applications for drug abuse monitoring. This technology has offered a low cost detection of narcotics; thereby, providing a confirmatory platform to compliment the existing analytical methods.
Article 0 Reads 2 Citations Promoter methylation-independent reactivation of PAX1 by curcumin and resveratrol is mediated by UHRF1 Gaurav Parashar, Neena Capalash Published: 17 June 2015
Clinical and Experimental Medicine, doi: 10.1007/s10238-015-0366-1
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Paired box gene1 (PAX1) is essential for normal chordate development and has been recently characterised to be a tumour suppressor gene which is frequently hypermethylated in different cancer types. We investigated the reactivation of PAX1 using curcumin and resveratrol in HeLa, SiHa and Caski cell lines and role of hypermethylation in 39 CpG sites of PAX1 promoter from -6 to -286 region in regulating its expression. Curcumin in HeLa and SiHa cells and resveratrol in Caski cells caused significant (P < 0.01) reactivation of PAX1 expression as shown by qRT PCR, but reversal of promoter hypermethylation was not observed across the three cell lines. Interestingly, even positive control 5-aza-2'-deoxycytidine was not found to be effective to cause demethylation of CpG sites under consideration suggesting the promoter region to be resistant towards hypomethylating effects as shown by bisulphite sequencing. However, a striking correlation between PAX1 reactivation and Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) downregulation after treatment with curcumin and resveratrol in HeLa, SiHa and Caski cell lines was observed which was further confirmed after transient silencing of UHRF1 expression. PAX1 reexpression was also obtained in Caski and SiHa cell lines after treatment with sodium butyrate, a histone deacetylase inhibitor, suggesting that PAX1 reactivation by curcumin and resveratrol may be due to their effect on histone deacetylase mediated through downregulation of UHRF1 which can regulate both DNA methylation and histone acetylation.