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Constantin Daniel Negut   Dr.  Senior Scientist or Principal Investigator 
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Constantin Daniel Negut published an article in December 2017.
Top co-authors
Mihaela Badea

46 shared publications

Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, Bucharest, Romania

Rodica Olar

31 shared publications

Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90–92 Panduri Str., 050663 Bucharest, Romania

Valentina Uivarosi

17 shared publications

Department of General and Inorganic Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956 Bucharest, Romania

Alexandra-Cristina Munteanu

1 shared publications

Department of General and Inorganic Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956 Bucharest, Romania

Constanţa Dulea

1 shared publications

PharmaServ. International SRL, 52 Sabinelor Str., 050853 Bucharest, Romania;(L.S.);(C.D.)

Publication Record
Distribution of Articles published per year 
(2004 - 2017)
Total number of journals
published in
Publications See all
Article 0 Reads 0 Citations Radiation processing for cultural heritage preservation – Romanian experience Ioan Valentin Moise, Mihaela Ene, Constantin Daniel Negut, M... Published: 01 December 2017
Nukleonika, doi: 10.1515/nuka-2017-0037
DOI See at publisher website ABS Show/hide abstract
Radiation sterilization has been considered a mass decontamination technique for biodegradable cultural heritage (CH) since its widespread application in the medical field. Initial experiments have revealed advantages, for example, efficiency and effectiveness, but also disadvantages, namely “side effects” concerning CH materials. More than 50 years later, the adequacy of ionizing radiation for some CH artefacts is still the subject of discussion. The main reason why is that science and industry are not yet able to provide a more efficient technique for treating mass decontamination. For wooden items, there is general agreement that the irradiation dose required for insect eradication is not damaging, even in the case of polychromed wood. For cellulose pulp (paper), there is a reduction in polymerization degree (DP) at the high doses necessary to stop the attack of fungi, but this should be considered taking into account the purpose of the treatment. Emergency or rescue treatments are necessary to mitigate the consequences of accidents or improper storage conditions. In some cases (archives), the value of written information is greater than the historical value of the paper support. For other materials, namely textiles, leather and parchment, less research has been published on the effect of ionizing radiation treatment. As a general rule, irradiation is not necessary when only a few CH elements are present that are affected by biological contamination since restorers can solve the problem by classical means. The need for radiation treatment arises when large collections (hundreds, thousands or even more elements) are heavily affected by the biological attack. In Romania, the IRASM gamma irradiator of IFIN-HH is receiving an increasing number of requests for CH treatment, mainly due to an intensive research programme concerning this topic and close liaison with CH owners or administrators. Besides reviewing the scientific results obtained in Romania and abroad, this paper presents some examples from experiences in Romania.
Article 1 Read 1 Citation Irradiation free radicals in freshwater crayfish Astacus leptodactylus Esch investigated by EPR spectroscopy V. Bercu, Constantin Daniel Negut, O.G. Duliu Published: 01 April 2017
Radiation Physics and Chemistry, doi: 10.1016/j.radphyschem.2016.12.008
DOI See at publisher website
BOOK-CHAPTER 0 Reads 0 Citations ESR Standard Methods for Detection of Irradiated Food Constantin Daniel Negut, M. Cutrubinis Published: 01 January 2017
Electron Spin Resonance in Food Science, doi: 10.1016/b978-0-12-805428-4.00001-5
DOI See at publisher website
BOOK-CHAPTER 3 Reads 0 Citations Chapter 19. Qualification and Certification of Ionizing Radiation Facilities Ioan Valentin Moise, Constantin Daniel Negut, Mihalis Cutrub... Published: 01 January 2017
Food Chemistry, Function and Analysis, doi: 10.1039/9781788010252-00383
DOI See at publisher website
Article 0 Reads 2 Citations Synthesis and Structural Investigation of New Bio-Relevant Complexes of Lanthanides with 5-Hydroxyflavone: DNA Binding a... Alexandra-Cristina Munteanu, Mihaela Badea, Rodica Olar, Lui... Published: 16 December 2016
Molecules, doi: 10.3390/molecules21121737
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
In the present work, we attempted to develop new metal coordination complexes of the natural flavonoid 5-hydroxyflavone with Sm(III), Eu(III), Gd(III), Tb(III). The resultant hydroxo complexes have been characterized by a variety of spectroscopic techniques, including fluorescence, FT-IR, UV-Vis, EPR and mass spectral studies. The general chemical formula of the complexes is [Ln(C15H9O3)3(OH)2(H2O)x]·nH2O, where Ln is the lanthanide cation and x = 0 for Sm(III), x = 1 for Eu(III), Gd(III), Tb(III) and n = 0 for Sm(III), Gd(III), Tb(III), n = 1 for Eu(III), respectively. The proposed structures of the complexes were optimized by DFT calculations. Theoretical calculations and experimental determinations sustain the proposed structures of the hydroxo complexes, with two molecules of 5-hydroxyflavone acting as monoanionic bidentate chelate ligands. The interaction of the complexes with calf thymus DNA has been explored by fluorescence titration and UV-Vis absorption binding studies, and revealed that the synthesized complexes interact with DNA with binding constants (Kb) ~ 104. Human serum albumin (HSA) and transferrin (Tf) binding studies have also been performed by fluorescence titration techniques (fluorescence quenching studies, synchronous fluorescence spectra). The apparent association constants (Ka) and thermodynamic parameters have been calculated from the fluorescence quenching experiment at 299 K, 308 K, and 318 K. The quenching curves indicate that the complexes bind to HSA with smaller affinity than the ligand, but to Tf with higher binding affinities than the ligand.
Article 1 Read 5 Citations Online Tests of an Optical Fiber Long-Period Grating Subjected to Gamma Irradiation Dan Sporea, A. Stancalie, D. Neguţ, Guillaume Pilorget, Sylv... Published: 01 December 2014
IEEE Photonics Journal, doi: 10.1109/jphot.2014.2337877
DOI See at publisher website